Rabbit Anti-NVL Recombinant Antibody (CBWJN-0818) (CBMAB-N4053-WJ)

Name: Rabbit Anti-NVL Recombinant Antibody (CBWJN-0818)
SKU: CBMAB-N4053-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBWJN-0818

Application

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.37 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nuclear VCP-Like

Introduction

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

Entrez Gene ID

4931

UniProt ID

O15381

Alternative Names

Nuclear VCP-Like; Nuclear Valosin-Containing Protein-Like; Nuclear VCP-Like Protein; NVLp; NVL2;

Function

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966).
Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824).
Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651).
Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).

Biological Process

Positive regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of telomerase activityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein localization to nucleolusManual Assertion Based On ExperimentIDA:UniProtKB
Ribosomal large subunit biogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Ribosome biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Isoform 2
Nucleus, nucleoplasm
Isoform 1
Nucleus, nucleolus
Nucleus, nucleoplasm
Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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