NVL

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin.

Full Name

Nuclear VCP-Like

Function

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966).
Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824).
Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651).
Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).

Biological Process

Positive regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of telomerase activityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein localization to nucleolusManual Assertion Based On ExperimentIDA:UniProtKB
Ribosomal large subunit biogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Ribosome biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Isoform 2
Nucleus, nucleoplasm
Isoform 1
Nucleus, nucleolus
Nucleus, nucleoplasm
Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.