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Mouse Anti-OLIG2 (AA 2-78) Recombinant Antibody (CBXO-0050) (CBMAB-O0388-CQ)

This product is a mouse antibody that recognizes OLIG2 (AA 2-78). The antibody CBXO-0050 can be used for immunoassay techniques such as: IP, WB, ELISA.
See all OLIG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0050
Antibody Isotype
IgG2a, Κ
Application
IP, WB, ELISA

Basic Information

Immunogen
OLIG2 (NP_005797, 2 a.a.-78 a.a) full length Recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-78

Target

Full Name
Oligodendrocyte Transcription Factor 2
Introduction
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
Entrez Gene ID
10215
UniProt ID
Q13516
Alternative Names
Oligodendrocyte Transcription Factor 2; Oligodendrocyte-Specific BHLH Transcription Factor 2; Basic Domain, Helix-Loop-Helix Protein, Class B, 1; Oligodendrocyte Lineage Transcription Factor 2; Human Protein Kinase C-Binding Protein RACK17; Class E Basic Helix-Loop-Helix Protein 19; Class B Basic Helix-Loop-Helix Protein 1; Protein Kinase C Binding Protein 2
Function
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Biological Process
MyelinationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Neuron fate commitmentIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Thalamus developmentIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
Involvement in disease
A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Fang, L. P., Liu, Q., Meyer, E., Welle, A., Huang, W., Scheller, A., ... & Bai, X. (2023). A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning. Glia, 71(2), 415-430.

Xu, J., Zhao, J., Wang, R., Zhang, Y., Shen, L., Xiao, Q., ... & Deng, W. (2022). Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke. Theranostics, 12(7), 3131.

Lee, J. E., Ahn, S., Jeong, H., An, S., Myung, C. H., Lee, J. A., ... & Hwang, J. S. (2021). Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells. Scientific reports, 11(1), 7778.

Sock, E., & Wegner, M. (2021). Using the lineage determinants Olig2 and Sox10 to explore transcriptional regulation of oligodendrocyte development. Developmental neurobiology, 81(7), 892-901.

Wei, H., Dong, X., You, Y., Hai, B., Duran, R. C. D., Wu, X., ... & Wu, J. Q. (2021). OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation. BMC biology, 19(1), 132.

Wang, H., Xu, L., Lai, C., Hou, K., Chen, J., Guo, Y., ... & Chen, G. (2021). Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord. Molecular brain, 14, 1-14.

Komatsu, H., Takeuchi, H., Kikuchi, Y., Ono, C., Yu, Z., Iizuka, K., ... & Tomita, H. (2020). Ethnicity-dependent effects of schizophrenia risk variants of the OLIG2 gene on OLIG2 transcription and white matter integrity. Schizophrenia Bulletin, 46(6), 1619-1628.

Bouchart, C., Trépant, A. L., Hein, M., Van Gestel, D., & Demetter, P. (2020). Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2. Cancer Medicine, 9(3), 1069-1078.

Wedel, M., Fröb, F., Elsesser, O., Wittmann, M. T., Lie, D. C., Reis, A., & Wegner, M. (2020). Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic acids research, 48(9), 4839-4857.

Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., ... & Jiang, P. (2019). OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome. Cell stem cell, 24(6), 908-926.

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For research use only. Not intended for any clinical use.

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