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OLIG2 Matched Antibody Pair (831) (APMAB-831LY)

This antibody pair set can be used for detecting and quantifying protein level of human OLIG2.
See all OLIG2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-OLIG2 monoclonal antibody, 100 ug
Detection Antibody
Anti-OLIG2 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Alternative Names
Oligodendrocyte Transcription Factor 2; Oligodendrocyte-Specific BHLH Transcription Factor 2; Basic Domain, Helix-Loop-Helix Protein, Class B, 1; Oligodendrocyte Lineage Transcription Factor 2; Human Protein Kinase C-Binding Protein RACK17; Class E Basic Helix-Loop-Helix Protein 19; Class B Basic Helix-Loop-Helix Protein 1; Protein Kinase C Binding Protein 2;
Entrez Gene ID
10215
UniProt ID
Q13516

Fang, L. P., Liu, Q., Meyer, E., Welle, A., Huang, W., Scheller, A., ... & Bai, X. (2023). A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning. Glia, 71(2), 415-430.

Xu, J., Zhao, J., Wang, R., Zhang, Y., Shen, L., Xiao, Q., ... & Deng, W. (2022). Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke. Theranostics, 12(7), 3131.

Lee, J. E., Ahn, S., Jeong, H., An, S., Myung, C. H., Lee, J. A., ... & Hwang, J. S. (2021). Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells. Scientific reports, 11(1), 7778.

Sock, E., & Wegner, M. (2021). Using the lineage determinants Olig2 and Sox10 to explore transcriptional regulation of oligodendrocyte development. Developmental neurobiology, 81(7), 892-901.

Wei, H., Dong, X., You, Y., Hai, B., Duran, R. C. D., Wu, X., ... & Wu, J. Q. (2021). OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation. BMC biology, 19(1), 132.

Wang, H., Xu, L., Lai, C., Hou, K., Chen, J., Guo, Y., ... & Chen, G. (2021). Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord. Molecular brain, 14, 1-14.

Komatsu, H., Takeuchi, H., Kikuchi, Y., Ono, C., Yu, Z., Iizuka, K., ... & Tomita, H. (2020). Ethnicity-dependent effects of schizophrenia risk variants of the OLIG2 gene on OLIG2 transcription and white matter integrity. Schizophrenia Bulletin, 46(6), 1619-1628.

Bouchart, C., Trépant, A. L., Hein, M., Van Gestel, D., & Demetter, P. (2020). Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2. Cancer Medicine, 9(3), 1069-1078.

Wedel, M., Fröb, F., Elsesser, O., Wittmann, M. T., Lie, D. C., Reis, A., & Wegner, M. (2020). Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic acids research, 48(9), 4839-4857.

Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., ... & Jiang, P. (2019). OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome. Cell stem cell, 24(6), 908-926.

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For research use only. Not intended for any clinical use.

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