Mouse Anti-ONECUT1 Recombinant Antibody (CBFYH-2687) (CBMAB-H3744-FY)

Name: Mouse Anti-ONECUT1 Recombinant Antibody (CBFYH-2687)
SKU: CBMAB-H3744-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2687

Application

IHC-P, IF

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ONECUT1

Introduction

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

3175

UniProt ID

Q9UBC0

Alternative Names

One Cut Homeobox 1; One Cut Domain Family Member 1; HNF6A; HNF-6; HNF6; Hepatocyte Nuclear Factor 6, Alpha; One Cut Domain, Family Member 1; Hepatocyte Nuclear Factor 6

Function

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Biological Process

Anatomical structure morphogenesisIEA:Ensembl
B cell differentiationIEA:Ensembl
Cell fate commitmentIEA:Ensembl
Cilium assemblyIEA:Ensembl
Endocrine pancreas developmentIEA:Ensembl
Endoderm developmentIEA:Ensembl
Epithelial cell developmentIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Liver developmentIEA:Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Regulation of cell-matrix adhesionIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Spleen developmentIEA:Ensembl

Cellular Location

Nucleus

Russ-Silsby, J., Patel, K. A., Laver, T. W., Hawkes, G., Johnson, M. B., Wakeling, M. N., ... & De Franco, E. (2023). The role of ONECUT1 variants in monogenic and type 2 diabetes mellitus. Diabetes, 72(11), 1729-1734.

Philippi, A., Heller, S., Costa, I. G., Senée, V., Breunig, M., Li, Z., ... & Kleger, A. (2021). Mutations and variants of ONECUT1 in diabetes. Nature Medicine, 27(11), 1928-1940.

Heller, S., Li, Z., Lin, Q., Geusz, R., Breunig, M., Hohwieler, M., ... & Costa, I. G. (2021). Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Communications biology, 4(1), 1298.

Patoori, S., Jean-Charles, N., Gopal, A., Sulaiman, S., Gopal, S., Wang, B., ... & Emerson, M. M. (2020). Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells. Neural Development, 15, 1-20.

Kropp, P. A., Zhu, X., & Gannon, M. (2019). Regulation of the pancreatic exocrine differentiation program and morphogenesis by Onecut 1/Hnf6. Cellular and Molecular Gastroenterology and Hepatology, 7(4), 841-856.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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