ONECUT1

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

ONECUT1

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Anatomical structure morphogenesisIEA:Ensembl
B cell differentiationIEA:Ensembl
Cell fate commitmentIEA:Ensembl
Cilium assemblyIEA:Ensembl
Endocrine pancreas developmentIEA:Ensembl
Endoderm developmentIEA:Ensembl
Epithelial cell developmentIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Liver developmentIEA:Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Regulation of cell-matrix adhesionIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Spleen developmentIEA:Ensembl

Nucleus