ONECUT1

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
Full Name
ONECUT1
Function
Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
Biological Process
Anatomical structure morphogenesisIEA:Ensembl
B cell differentiationIEA:Ensembl
Cell fate commitmentIEA:Ensembl
Cilium assemblyIEA:Ensembl
Endocrine pancreas developmentIEA:Ensembl
Endoderm developmentIEA:Ensembl
Epithelial cell developmentIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Liver developmentIEA:Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Regulation of cell-matrix adhesionIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Spleen developmentIEA:Ensembl
Cellular Location
Nucleus
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Anti-ONECUT1 antibodies

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Mouse Anti-ONECUT1 Recombinant Antibody (CBFYH-2690) (CBMAB-H3747-FY)

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Target: ONECUT1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYH-2690
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ONECUT1 (AA 85-198) Recombinant Antibody (CBFYH-2689) (CBMAB-H3746-FY)

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Target: ONECUT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2689
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-ONECUT1 (AA 85-198) Recombinant Antibody (CBFYH-2688) (CBMAB-H3745-FY)

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Target: ONECUT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2688
Application*: IF, IH, P, WB
Datasheet SDS

Mouse Anti-ONECUT1 Recombinant Antibody (CBFYH-2687) (CBMAB-H3744-FY)

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Target: ONECUT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2687
Application*: P, IF
Datasheet SDS

Mouse Anti-ONECUT1 Recombinant Antibody (CBXO-0565) (CBMAB-O0451-CQ)

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Target: ONECUT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0565
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-ONECUT1 Antibody (1A1) (CBMAB-0769-YC)

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Target: ONECUT1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Frog
Clone: 1A1
Application*: IP, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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