Mouse Anti-ORM1 Recombinant Antibody (CBXO-0079) (CBMAB-O0567-CQ)

Name: Mouse Anti-ORM1 Recombinant Antibody (CBXO-0079)
SKU: CBMAB-O0567-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0079

Application

ELISA, WB, IHC-P, IP

Specificity

Human

Antibody Isotype

IgG1, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Orosomucoid 1

Introduction

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.

Entrez Gene ID

5004

UniProt ID

P02763

Alternative Names

Orosomucoid 1; AGP 1; OMD 1; AGP1; Epididymis Secretory Sperm Binding Protein Li 153w; Alpha-1-Acid Glycoprotein 1

Function

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Biological Process

Acute-phase responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune system processIEA:InterPro

Cellular Location

Secreted

PTM

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

He, J., Zheng, Z., Liu, T., Ao, Y., Yang, Y., & Hu, H. (2022). Salivary orosomucoid 1 as a biomarker of hepatitis B associated hepatocellular carcinoma. Scientific Reports, 12(1), 15347.

Sánchez-Romero, C., Bologna-Molina, R., González-González, R., Salazar-Rodríguez, S., & Mendoza, N. B. (2021). Comparison of orosomucoid-1 immunoexpression and angiogenesis between oral squamous cell carcinoma cases with different histological grades. Journal of Oral and Maxillofacial Pathology, 25(2), 368.

Elpek, G. O. (2021). Orosomucoid in liver diseases. World Journal of Gastroenterology, 27(45), 7739.

Qiong, L., & Yin, J. (2021). Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9. Bioengineered, 12(1), 8822-8832.

McGuckin, M. M., Giesy, S. L., Davis, A. N., Abyeta, M. A., Horst, E. A., Samii, S. S., ... & Boisclair, Y. R. (2020). The acute phase protein orosomucoid 1 is upregulated in early lactation but does not trigger appetite-suppressing STAT3 signaling via the leptin receptor. Journal of dairy science, 103(5), 4765-4776.

Higuchi, H., Kamimura, D., Jiang, J. J., Atsumi, T., Iwami, D., Hotta, K., ... & Murakami, M. (2020). Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation. International immunology, 32(5), 335-346.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

ORM1 Matched Antibody Pair (834) (CAT#: APMAB-834LY)

ORM1 Matched Antibody Pair (835) (CAT#: APMAB-835LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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