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ORM1

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Full Name

Orosomucoid 1

Function

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Biological Process

Acute-phase responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune system processIEA:InterPro

Cellular Location

Secreted

PTM

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

Anti-ORM1 antibodies

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0428) (CBMAB-O0573-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Pig

Clone: CBXO-0428

Application*: WB, P, PE

Mouse Anti-ORM1 (AA 18-201) Recombinant Antibody (CBXO-0076) (CBMAB-O0562-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0076

Application*: IP, SE, IR, E, WB, P

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0077) (CBMAB-O0563-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXO-0077

Application*: E, IH, WB

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0078) (CBMAB-O0565-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXO-0078

Application*: E, WB

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0411) (CBMAB-O0566-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXO-0411

Application*: E, WB, IH, IF

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0079) (CBMAB-O0567-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0079

Application*: E, WB, P, IP

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0080) (CBMAB-O0568-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0080

Application*: WB, P

Rat Anti-ORM1 Recombinant Antibody (CBXO-0507) (CBMAB-O0569-CQ)

SDS

Target: ORM1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXO-0507

Application*: IP, WB

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0237) (CBMAB-O0570-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0237

Application*: IH, WB

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0561) (CBMAB-O0571-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXO-0561

Application*: WB

Mouse Anti-ORM1 Recombinant Antibody (CBXO-0483) (CBMAB-O0572-CQ)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBXO-0483

Application*: WB, P

Rat Anti-ORM1 Recombinant Antibody (10K30) (CBMAB-A4637-YC)

SDS

Target: ORM1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 10K30

Application*: IP, WB

Mouse Anti-ORM1 Recombinant Antibody (9H10) (CBMAB-A4639-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9H10

Application*: E, IH, WB

Mouse Anti-ORM1 Recombinant Antibody (AGP-47) (CBMAB-A4640-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Baboon

Clone: AGP-47

Application*: WB, E

Mouse Anti-ORM1 Recombinant Antibody (C1) (CBMAB-A4641-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: C1

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-ORM1 Recombinant Antibody (C2) (CBMAB-A4642-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: C2

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-ORM1 Recombinant Antibody (GPB2) (CBMAB-A4643-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle

Clone: GPB2

Application*: WB, E

Mouse Anti-ORM1 Recombinant Antibody (GPB6) (CBMAB-A4644-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Cattle

Clone: GPB6

Application*: WB, E

Mouse Anti-ORM1 Recombinant Antibody (GPF7-2) (CBMAB-A4645-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Cattle

Clone: GPF7-2

Application*: WB, E

Mouse Anti-ORM1 Recombinant Antibody (CBYC-A1016) (CBMAB-A4646-YC)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-A1016

Application*: WB, IH

Mouse Anti-ORM1 Recombinant Antibody (CAP956) (CBMAB-AP3052LY)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: CAP956

Application*: ICC, IHC, IP, WB

Mouse Anti-ORM1 Recombinant Antibody (CAP957) (CBMAB-AP3053LY)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CAP957

Application*: ICC, IHC, IP, WB

Mouse Anti-ORM1 Recombinant Antibody (CAP958) (CBMAB-AP3054LY)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: CAP958

Application*: ICC, IHC, IP, WB

Mouse Anti-ORM1 Recombinant Antibody (CAP959) (CBMAB-AP3055LY)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CAP959

Application*: ICC, IHC, IP, WB

Mouse Anti-ORM1 Recombinant Antibody (CAP960) (CBMAB-AP3056LY)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CAP960

Application*: ICC, IHC, IP, WB

Mouse Anti-ORM1 Recombinant Antibody (CAP961) (CBMAB-AP3057LY)

SDS

Target: ORM1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CAP961

Application*: ICC, IHC, IP, WB

ORM1 Matched Antibody Pair (835) (APMAB-835LY)

SDS

Target: ORM1

Specificity: Human

ORM1 Matched Antibody Pair (834) (APMAB-834LY)

SDS

Target: ORM1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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