ORM1
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Full Name
Orosomucoid 1
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Biological Process
Acute-phase responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune system processIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune system processIEA:InterPro
Cellular Location
Secreted
PTM
N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
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Anti-ORM1 antibodies
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CompareTarget: ORM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: GPB6
Application*: WB, E
Target: ORM1
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-30 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: ORM1
Specificity: Human
Target: ORM1
Specificity: Human
Target: ORM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP961
Application*: ICC, IHC, IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP960
Application*: ICC, IHC, IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP959
Application*: ICC, IHC, IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP958
Application*: ICC, IHC, IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP957
Application*: ICC, IHC, IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP956
Application*: ICC, IHC, IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-A1016
Application*: WB, IH
Target: ORM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: GPF7-2
Application*: WB, E
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: GPB2
Application*: WB, E
Target: ORM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C2
Application*: WB, IC, P, C, E, IP, IF, F
Target: ORM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C1
Application*: WB, IC, P, C, E, IP, IF, F
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Baboon
Clone: AGP-47
Application*: WB, E
Target: ORM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9H10
Application*: E, IH, WB
Target: ORM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 10K30
Application*: IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig
Clone: CBXO-0428
Application*: WB, P, PE
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXO-0483
Application*: WB, P
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0561
Application*: WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0237
Application*: IH, WB
Target: ORM1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXO-0507
Application*: IP, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0080
Application*: WB, P
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0079
Application*: E, WB, P, IP
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0411
Application*: E, WB, IH, IF
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0078
Application*: E, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0077
Application*: E, IH, WB
Target: ORM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0076
Application*: IP, SE, IR, E, WB, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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