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Rat Anti-OSTN (AA 28-130) Recombinant Antibody (311417) (CBMAB-O0659-CQ)

This product is a rat antibody that recognizes OSTN (AA 28-130). The antibody 311417 can be used for immunoassay techniques such as: IP, WB.
See all OSTN antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
311417
Antibody Isotype
IgG2a
Application
IP, WB

Basic Information

Immunogen
E. coli-derived recombinant mouse Osteocrin Val28-Gly130
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS with 5% trehalose
Preservative
None
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 28-130

Target

Full Name
Osteocrin
Introduction
OSTN (Osteocrin) is a Protein Coding gene. Diseases associated with OSTN include Acromesomelic Dysplasia. Gene Ontology (GO) annotations related to this gene include receptor binding and hormone activity.
Entrez Gene ID
Human344901
Mouse239790
UniProt ID
HumanP61366
MouseP61364
Alternative Names
Osteocrin; MUSCLIN
Function
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782).
Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782).
Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cell surface receptor signaling pathwayIEA:Ensembl
Endochondral bone growthIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dendrite extensionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of glucose importIEA:Ensembl
Negative regulation of osteoblast differentiationIEA:Ensembl
Cellular Location
Secreted

Nishiguchi, Y., Hata, Y., Date, R., Fujimoto, D., Umemoto, S., Kanki, T., ... & Kuwabara, T. (2022). Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice. Nephrology Dialysis Transplantation, 37(3), 444-453.

Ji, M., Zuo, Z., Zhang, M., Xu, Z., & Hu, G. (2022). Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides, 152, 170773.

Watanabe-Takano, H., Ochi, H., Chiba, A., Matsuo, A., Kanai, Y., Fukuhara, S., ... & Mochizuki, N. (2021). Mechanical load regulates bone growth via periosteal Osteocrin. Cell reports, 36(2).

Tsukada, T. (2021). Osteocrin. In Handbook of Hormones (pp. 601-603). Academic Press.

Zhang, X., Hu, C., Yuan, X. P., Yuan, Y. P., Song, P., Kong, C. Y., ... & Tang, Q. Z. (2021). Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity. Cell Death & Disease, 12(7), 624.

Handa, T., Mori, K. P., Ishii, A., Ohno, S., Kanai, Y., Watanabe-Takano, H., ... & Yokoi, H. (2021). Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition. Scientific Reports, 11(1), 21835.

Wang, J. S., Kamath, T., Mazur, C. M., Mirzamohammadi, F., Rotter, D., Hojo, H., ... & Wein, M. N. (2021). Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Nature communications, 12(1), 6271.

NISHIGUCHI, Y., Kuwabara, T., Fujimoto, D., Kanki, T., Hata, Y., Yokoi, H., ... & Mukoyama, M. (2020). SUN-004 Osteocrin, a bone-originated humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice. Kidney International Reports, 5(3), S206.

Hu, C., Zhang, X., Zhang, N., Wei, W. Y., Li, L. L., Ma, Z. G., & Tang, Q. Z. (2020). Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity. Clinical and Translational Medicine, 10(3), e124.

Watanabe-Takano, H., Ochi, H., Chiba, A., Matsuo, A., Kanai, Y., Fukuhara, S., ... & Mochizuki, N. (2019). Periosteum-derived Osteocrin regulates bone growth through both endochondral ossification and intramembranous ossification. BioRxiv, 697094.

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For research use only. Not intended for any clinical use.

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