Rat Anti-OSTN (AA 28-130) Recombinant Antibody (311417) (CBMAB-O0659-CQ)

Name: Rat Anti-OSTN (AA 28-130) Recombinant Antibody (311417)
SKU: CBMAB-O0659-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

311417

Application

IP, WB

Immunogen

E. coli-derived recombinant mouse Osteocrin Val28-Gly130

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS with 5% trehalose

Preservative

None

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 28-130

More Infomation

Target

Full Name

Osteocrin

Introduction

OSTN (Osteocrin) is a Protein Coding gene. Diseases associated with OSTN include Acromesomelic Dysplasia. Gene Ontology (GO) annotations related to this gene include receptor binding and hormone activity.

Entrez Gene ID

Human	344901
Mouse	239790

UniProt ID

Human	P61366
Mouse	P61364

Alternative Names

Osteocrin; MUSCLIN

Function

Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782).
Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782).
Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cell surface receptor signaling pathwayIEA:Ensembl
Endochondral bone growthIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dendrite extensionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of glucose importIEA:Ensembl
Negative regulation of osteoblast differentiationIEA:Ensembl

Cellular Location

Secreted

Nishiguchi, Y., Hata, Y., Date, R., Fujimoto, D., Umemoto, S., Kanki, T., ... & Kuwabara, T. (2022). Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice. Nephrology Dialysis Transplantation, 37(3), 444-453.

Ji, M., Zuo, Z., Zhang, M., Xu, Z., & Hu, G. (2022). Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides, 152, 170773.

Watanabe-Takano, H., Ochi, H., Chiba, A., Matsuo, A., Kanai, Y., Fukuhara, S., ... & Mochizuki, N. (2021). Mechanical load regulates bone growth via periosteal Osteocrin. Cell reports, 36(2).

Tsukada, T. (2021). Osteocrin. In Handbook of Hormones (pp. 601-603). Academic Press.

Zhang, X., Hu, C., Yuan, X. P., Yuan, Y. P., Song, P., Kong, C. Y., ... & Tang, Q. Z. (2021). Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity. Cell Death & Disease, 12(7), 624.

Handa, T., Mori, K. P., Ishii, A., Ohno, S., Kanai, Y., Watanabe-Takano, H., ... & Yokoi, H. (2021). Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition. Scientific Reports, 11(1), 21835.

Wang, J. S., Kamath, T., Mazur, C. M., Mirzamohammadi, F., Rotter, D., Hojo, H., ... & Wein, M. N. (2021). Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Nature communications, 12(1), 6271.

NISHIGUCHI, Y., Kuwabara, T., Fujimoto, D., Kanki, T., Hata, Y., Yokoi, H., ... & Mukoyama, M. (2020). SUN-004 Osteocrin, a bone-originated humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice. Kidney International Reports, 5(3), S206.

Hu, C., Zhang, X., Zhang, N., Wei, W. Y., Li, L. L., Ma, Z. G., & Tang, Q. Z. (2020). Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity. Clinical and Translational Medicine, 10(3), e124.

Watanabe-Takano, H., Ochi, H., Chiba, A., Matsuo, A., Kanai, Y., Fukuhara, S., ... & Mochizuki, N. (2019). Periosteum-derived Osteocrin regulates bone growth through both endochondral ossification and intramembranous ossification. BioRxiv, 697094.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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