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OSTN

OSTN is a Protein Coding gene. Diseases associated with OSTN include Acromesomelic Dysplasia. Gene Ontology annotations related to this gene include receptor binding and hormone activity.

Full Name

Osteocrin

Function

Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782).
Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782).
Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

Biological Process

Cell differentiationIEA:UniProtKB-KW
Cell surface receptor signaling pathwayIEA:Ensembl
Endochondral bone growthIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dendrite extensionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of glucose importIEA:Ensembl
Negative regulation of osteoblast differentiationIEA:Ensembl

Cellular Location

Secreted

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Anti-OSTN antibodies

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Human OSTN ELISA Kit (V2LY-0626-LY4144)

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Target: OSTN

Sensitivity: 0.023 ng/mL

Detection Range: 0.05-20 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Ostn ELISA Kit (V2LY-0626-LY2819)

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Target: Ostn

Sensitivity: 0.005 ng/mL

Detection Range: 0.01-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Mouse Anti-OSTN Recombinant Antibody (CBFYM-3042) (CBMAB-M3238-FY)

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Target: OSTN

Host: Mouse

Specificity: Human

Clone: CBFYM-3042

Application*: WB, IP, IF, E

Rat Anti-OSTN Recombinant Antibody (CBXO-0248) (CBMAB-O0661-CQ)

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Target: OSTN

Host: Rat

Specificity: Mouse

Clone: CBXO-0248

Application*: IP, WB

Rat Anti-OSTN (AA 28-130) Recombinant Antibody (CBXO-0379) (CBMAB-O0660-CQ)

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Target: OSTN

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBXO-0379

Application*: WB

Rat Anti-OSTN (AA 28-130) Recombinant Antibody (311417) (CBMAB-O0659-CQ)

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Target: OSTN

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 311417

Application*: IP, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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