Mouse Ostn ELISA Kit (V2LY-0626-LY2819)

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Tested Data
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Basic Information

Sensitivity
0.005 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
14.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Osteocrin
Function
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782).
Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782).
Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cell surface receptor signaling pathwayIEA:Ensembl
Endochondral bone growthIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dendrite extensionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of glucose importIEA:Ensembl
Negative regulation of osteoblast differentiationIEA:Ensembl
Cellular Location
Secreted

Nishiguchi, Y., Hata, Y., Date, R., Fujimoto, D., Umemoto, S., Kanki, T., ... & Kuwabara, T. (2022). Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice. Nephrology Dialysis Transplantation, 37(3), 444-453.

Ji, M., Zuo, Z., Zhang, M., Xu, Z., & Hu, G. (2022). Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress. Peptides, 152, 170773.

Watanabe-Takano, H., Ochi, H., Chiba, A., Matsuo, A., Kanai, Y., Fukuhara, S., ... & Mochizuki, N. (2021). Mechanical load regulates bone growth via periosteal Osteocrin. Cell reports, 36(2).

Tsukada, T. (2021). Osteocrin. In Handbook of Hormones (pp. 601-603). Academic Press.

Zhang, X., Hu, C., Yuan, X. P., Yuan, Y. P., Song, P., Kong, C. Y., ... & Tang, Q. Z. (2021). Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity. Cell Death & Disease, 12(7), 624.

Handa, T., Mori, K. P., Ishii, A., Ohno, S., Kanai, Y., Watanabe-Takano, H., ... & Yokoi, H. (2021). Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition. Scientific Reports, 11(1), 21835.

Wang, J. S., Kamath, T., Mazur, C. M., Mirzamohammadi, F., Rotter, D., Hojo, H., ... & Wein, M. N. (2021). Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Nature communications, 12(1), 6271.

NISHIGUCHI, Y., Kuwabara, T., Fujimoto, D., Kanki, T., Hata, Y., Yokoi, H., ... & Mukoyama, M. (2020). SUN-004 Osteocrin, a bone-originated humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice. Kidney International Reports, 5(3), S206.

Hu, C., Zhang, X., Zhang, N., Wei, W. Y., Li, L. L., Ma, Z. G., & Tang, Q. Z. (2020). Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity. Clinical and Translational Medicine, 10(3), e124.

Watanabe-Takano, H., Ochi, H., Chiba, A., Matsuo, A., Kanai, Y., Fukuhara, S., ... & Mochizuki, N. (2019). Periosteum-derived Osteocrin regulates bone growth through both endochondral ossification and intramembranous ossification. BioRxiv, 697094.

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For research use only. Not intended for any clinical use.

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