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Mouse Anti-OTX1 Recombinant Antibody (1F2) (CBMAB-O0731-CQ)

This product is a mouse antibody that recognizes OTX1. The antibody 1F2 can be used for immunoassay techniques such as: ELISA, IF, RNAi, WB.
See all OTX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F2
Antibody Isotype
IgG2a, Κ
Application
ELISA, IF, RNAi, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
orthodenticle homeobox 1
Introduction
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
5013
UniProt ID
P32242
Alternative Names
Orthodenticle Homeobox 1; Orthodenticle (Drosophila) Homolog 1; Orthodenticle Homolog 1 (Drosophila); Orthodenticle Homolog 1
Function
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Biological Process
Anterior/posterior pattern specificationIEA:Ensembl
Diencephalon morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Metencephalon developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Wei, J., Wang, X., Jiao, K., & Liu, H. (2023). Orthodenticle Homeobox OTX1 Promotes Papillary Thyroid Carcinoma Progression and Is a Potential Prognostic Biomarker. Genetics Research, 2023, e33.

Yang, R., Yang, L., Long, M., Wu, F., Shi, Y., Xia, R., ... & Wei, W. (2023). Taurodeoxycholic acid-YAP1 upregulates OTX1 in promoting gallbladder cancer malignancy through IFITM3-dependent AKT activation. Oncogene, 42(18), 1466-1477.

Zhou, L., Li, H., Zhang, D., Chen, L., Dong, H., Yuan, Y., & Wang, T. (2022). OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway. Oncology Reports, 48(5), 1-11.

Jiang, L., Zuo, Z., Lin, J., & Yang, C. (2021). Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. Bioengineered, 12(1), 6559-6571.

Yang, C. Y., Wang, L., Mu, D. C., Li, F. F., Ran, P. Z., Shen, H., ... & Zheng, S. Y. (2020). OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma. European Review for Medical & Pharmacological Sciences, 24(18).

Chen, S., Xu, M., Zhao, J., Shen, J., Li, J., Liu, Y., ... & Shan, T. (2020). MicroRNA-4516 suppresses pancreatic cancer development via negatively regulating orthodenticle homeobox 1. International journal of biological sciences, 16(12), 2159.

Tu, X. P., Li, H., Chen, L. S., Luo, X. N., Lu, Z. M., Zhang, S. Y., & Chen, S. H. (2020). OTX1 exerts an oncogenic role and is negatively regulated by miR129-5p in laryngeal squamous cell carcinoma. BMC cancer, 20, 1-10.

Li, J., Zhao, L. M., Zhang, C., Li, M., Gao, B., Hu, X. H., ... & Wang, G. Y. (2020). The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p. Oncology research, 28(1), 51.

Yang, J., Wu, W., Wu, M., & Ding, J. (2019). Long noncoding RNA ADPGK-AS1 promotes cell proliferation, migration, and EMT process through regulating miR-3196/OTX1 axis in breast cancer. In Vitro Cellular & Developmental Biology-Animal, 55(7), 522-532.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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