Rabbit Anti-OTX1 Recombinant Antibody (CBXO-0155) (CBMAB-O0733-CQ)

Name: Rabbit Anti-OTX1 Recombinant Antibody (CBXO-0155)
SKU: CBMAB-O0733-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXO-0155

Application

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

2.487 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

orthodenticle homeobox 1

Introduction

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	5013
Mouse	18423
Rat	25646

UniProt ID

Human	P32242
Mouse	P80205
Rat	Q63410

Alternative Names

Orthodenticle Homeobox 1; Orthodenticle (Drosophila) Homolog 1; Orthodenticle Homolog 1 (Drosophila); Orthodenticle Homolog 1

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Biological Process

Anterior/posterior pattern specificationIEA:Ensembl
Diencephalon morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Metencephalon developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Wei, J., Wang, X., Jiao, K., & Liu, H. (2023). Orthodenticle Homeobox OTX1 Promotes Papillary Thyroid Carcinoma Progression and Is a Potential Prognostic Biomarker. Genetics Research, 2023, e33.

Yang, R., Yang, L., Long, M., Wu, F., Shi, Y., Xia, R., ... & Wei, W. (2023). Taurodeoxycholic acid-YAP1 upregulates OTX1 in promoting gallbladder cancer malignancy through IFITM3-dependent AKT activation. Oncogene, 42(18), 1466-1477.

Zhou, L., Li, H., Zhang, D., Chen, L., Dong, H., Yuan, Y., & Wang, T. (2022). OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway. Oncology Reports, 48(5), 1-11.

Jiang, L., Zuo, Z., Lin, J., & Yang, C. (2021). Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. Bioengineered, 12(1), 6559-6571.

Yang, C. Y., Wang, L., Mu, D. C., Li, F. F., Ran, P. Z., Shen, H., ... & Zheng, S. Y. (2020). OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma. European Review for Medical & Pharmacological Sciences, 24(18).

Chen, S., Xu, M., Zhao, J., Shen, J., Li, J., Liu, Y., ... & Shan, T. (2020). MicroRNA-4516 suppresses pancreatic cancer development via negatively regulating orthodenticle homeobox 1. International journal of biological sciences, 16(12), 2159.

Tu, X. P., Li, H., Chen, L. S., Luo, X. N., Lu, Z. M., Zhang, S. Y., & Chen, S. H. (2020). OTX1 exerts an oncogenic role and is negatively regulated by miR129-5p in laryngeal squamous cell carcinoma. BMC cancer, 20, 1-10.

Li, J., Zhao, L. M., Zhang, C., Li, M., Gao, B., Hu, X. H., ... & Wang, G. Y. (2020). The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p. Oncology research, 28(1), 51.

Yang, J., Wu, W., Wu, M., & Ding, J. (2019). Long noncoding RNA ADPGK-AS1 promotes cell proliferation, migration, and EMT process through regulating miR-3196/OTX1 axis in breast cancer. In Vitro Cellular & Developmental Biology-Animal, 55(7), 522-532.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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