OTX1
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy. [provided by RefSeq]
Full Name
orthodenticle homeobox 1
Function
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Biological Process
Anterior/posterior pattern specificationIEA:Ensembl
Diencephalon morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Metencephalon developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Diencephalon morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Metencephalon developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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Anti-OTX1 antibodies
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Target: OTX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E5
Application*: WB, E
Target: OTX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXO-0155
Application*: WB
Target: OTX1
Host: Mouse
Specificity: Human
Clone: 3A5
Application*: WB, IP, IF, E
Target: OTX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F2
Application*: E, IF, IR, WB
Target: OTX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D12
Application*: E, IF, WB
Target: OTX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: Otx-5F5
Application*: WB
Target: OTX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: BA0236
Application*: CI, P, WB
Target: OTX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: BA0333
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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