Mouse Anti-PAEP Recombinant Antibody (16) (CBMAB-AO834LY)

Name: Mouse Anti-PAEP Recombinant Antibody (16)
SKU: CBMAB-AO834LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

Antibody Isotype

IgG1

Application

ELISA, IHC

Basic Information

Immunogen

Placental protein 14 (glycodelin A) purified from second trimester amniotic fluid

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Progestagen Associated Endometrial Protein

Introduction

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Entrez Gene ID

5047

UniProt ID

P09466

Alternative Names

glycodelin A; GD; Pregnancy-associated endometrial alpha-2 globulin; PEG; PAEG; Placental protein 14; PP14; Progesterone-associated endometrial potein; Progestagen-associated endometrial protein

Function

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163).
Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260).
Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671).
Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).

Biological Process

Apoptotic processManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of sperm capacitationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIDA:CACAO
Regulation of binding of sperm to zona pellucidaManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted

PTM

Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.

More Infomation

References

Lataifeh, L., Alzghoul, S., Al Masoud, E., Mousa, B. A., & Al Sharie, A. H. (2023). 249P The prognostic utility of Progestogen associated Endometrial protein (PAEP) gene expression in clear cell renal cell carcinoma (ccRCC). Annals of Oncology, 34, S1569-S1570.

Liu, J., Wang, Z., Zhou, J., Wang, J., He, X., & Wang, J. (2023). Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer. Chinese Medical Journal, 136(21), 2576-2586.

Pearson-Farr, J. E., Wheway, G., Jongen, M. S., Goggin, P., Lewis, R. M., Cheong, Y., & Cleal, J. K. (2022). Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss. Reproduction and Fertility, 3(3), 162-172.

Pearson-Farr, J. E., Wheway, G., Jongen, M. S. A., Goggin, P., Lewis, R. M., Cheong, Y., & Cleal, J. K. (2021). PAEP and cilia gene splicing changes in endometrial glands during the implantation window in women with recurrent pregnancy loss. bioRxiv, 2021-09.

Kolenda, M., Sitkowska, B., Kamola, D., & Lambert, B. D. (2021). Composite genotypes of progestogen-associated endometrial protein gene and their association with composition and quality of dairy cattle milk. Animal bioscience, 34(8), 1283.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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