Human PAEP ELISA Kit (2) (V2LY-0626-LY5922)

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Datasheet
SDS
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Basic Information

Sensitivity
2.32 ng/mL
Detection Range
5-500 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
20.6 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Progestagen Associated Endometrial Protein
Function
Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163).
Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260).
Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671).
Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).
Biological Process
Apoptotic processManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of sperm capacitationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIDA:CACAO
Regulation of binding of sperm to zona pellucidaManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
PTM
Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.

Lataifeh, L., Alzghoul, S., Al Masoud, E., Mousa, B. A., & Al Sharie, A. H. (2023). 249P The prognostic utility of Progestogen associated Endometrial protein (PAEP) gene expression in clear cell renal cell carcinoma (ccRCC). Annals of Oncology, 34, S1569-S1570.

Liu, J., Wang, Z., Zhou, J., Wang, J., He, X., & Wang, J. (2023). Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer. Chinese Medical Journal, 136(21), 2576-2586.

Pearson-Farr, J. E., Wheway, G., Jongen, M. S., Goggin, P., Lewis, R. M., Cheong, Y., & Cleal, J. K. (2022). Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss. Reproduction and Fertility, 3(3), 162-172.

Pearson-Farr, J. E., Wheway, G., Jongen, M. S. A., Goggin, P., Lewis, R. M., Cheong, Y., & Cleal, J. K. (2021). PAEP and cilia gene splicing changes in endometrial glands during the implantation window in women with recurrent pregnancy loss. bioRxiv, 2021-09.

Kolenda, M., Sitkowska, B., Kamola, D., & Lambert, B. D. (2021). Composite genotypes of progestogen-associated endometrial protein gene and their association with composition and quality of dairy cattle milk. Animal bioscience, 34(8), 1283.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human PAEP ELISA Kit (CAT#: V2LY-0626-LY3949)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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