Human PAEP ELISA Kit (V2LY-0626-LY3949)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.028 μg/mL
Detection Range
0.05-20 μg/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
20.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Progestagen Associated Endometrial Protein
Function
Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163).
Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260).
Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671).
Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).
Biological Process
Apoptotic processManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of sperm capacitationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIDA:CACAO
Regulation of binding of sperm to zona pellucidaManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
PTM
Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.

Lataifeh, L., Alzghoul, S., Al Masoud, E., Mousa, B. A., & Al Sharie, A. H. (2023). 249P The prognostic utility of Progestogen associated Endometrial protein (PAEP) gene expression in clear cell renal cell carcinoma (ccRCC). Annals of Oncology, 34, S1569-S1570.

Liu, J., Wang, Z., Zhou, J., Wang, J., He, X., & Wang, J. (2023). Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer. Chinese Medical Journal, 136(21), 2576-2586.

Pearson-Farr, J. E., Wheway, G., Jongen, M. S., Goggin, P., Lewis, R. M., Cheong, Y., & Cleal, J. K. (2022). Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss. Reproduction and Fertility, 3(3), 162-172.

Pearson-Farr, J. E., Wheway, G., Jongen, M. S. A., Goggin, P., Lewis, R. M., Cheong, Y., & Cleal, J. K. (2021). PAEP and cilia gene splicing changes in endometrial glands during the implantation window in women with recurrent pregnancy loss. bioRxiv, 2021-09.

Kolenda, M., Sitkowska, B., Kamola, D., & Lambert, B. D. (2021). Composite genotypes of progestogen-associated endometrial protein gene and their association with composition and quality of dairy cattle milk. Animal bioscience, 34(8), 1283.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human PAEP ELISA Kit (2) (CAT#: V2LY-0626-LY5922)

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Human PAEP ELISA Kit (2) (CAT#: V2LY-0626-LY5922)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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