Rabbit Anti-PAK3 Recombinant Antibody (CBYC-P147) (CBMAB-P0703-YC)

Name: Rabbit Anti-PAK3 Recombinant Antibody (CBYC-P147)
SKU: CBMAB-P0703-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYC-P147

Application

IHC, IP, WB

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

p21 protein (Cdc42/Rac)-activated kinase 3

Introduction

PAK3 is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability.

Entrez Gene ID

5063

UniProt ID

O75914

Alternative Names

P21 (RAC1) Activated Kinase 3; P21 Protein (Cdc42/Rac)-Activated Kinase 3; P21 (CDKN1A)-Activated Kinase 3; Oligophrenin-3; EC 2.7.11.1; Beta-PAK; OPHN3; PAK-3; Serine/Threonine-Protein Kinase PAK 3; Adriamycin Resistance-Associated;

Function

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity).

Biological Process

AxonogenesisISS:UniProtKB
Cellular response to organic cyclic compoundIEA:Ensembl
Dendrite developmentISS:UniProtKB
Dendritic spine morphogenesisISS:UniProtKB
Ephrin receptor signaling pathwayTAS:Reactome
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of dendritic spine morphogenesisIEA:Ensembl
Positive regulation of DNA biosynthetic processIEA:Ensembl
Positive regulation of fibroblast migrationIEA:Ensembl
Positive regulation of neuron apoptotic processIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of actin filament polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Stimulatory C-type lectin receptor signaling pathwayTAS:Reactome
Synapse organizationManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Intellectual developmental disorder, X-linked 30 (XLID30):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

PTM

Autophosphorylated when activated by CDC42/p21.
Neddylated.

Dobrigna, M., Poëa-Guyon, S., Rousseau, V., Vincent, A., Toutain, A., & Barnier, J. V. (2023). The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype. Frontiers in Neuroscience, 17, 1123784.

Liu, H., Liu, K., & Dong, Z. (2021). The role of p21-activated kinases in cancer and beyond: where are we heading?. Frontiers in cell and developmental biology, 9, 641381.

Bautista, L., Knippler, C. M., & Ringel, M. D. (2020). p21-Activated kinases in thyroid cancer. Endocrinology, 161(8), bqaa105.

Wu, H. Y., Yang, M. C., Ding, L. Y., Chen, C. S., & Chu, P. C. (2019). p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells. Cancer letters, 456, 13-22.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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