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Mouse Anti-PALM Recombinant Antibody (4E1) (CBMAB-A6310-LY)

The product is antibody recognizes PALM. The antibody 4E1 immunoassay techniques such as: WB, ELISA.
See all PALM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E1
Antibody Isotype
IgG3, κ
Application
WB, ELISA

Basic Information

Immunogen
PALM (NP_005839, 176 a.a. ~ 284 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
paralemmin
Introduction
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]
Entrez Gene ID
5064
UniProt ID
O75781
Alternative Names
KIAA0270
Function
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular response to electrical stimulusIEA:Ensembl
Cytoskeleton organizationIEA:Ensembl
Negative regulation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dopamine receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneIEA:Ensembl
Regulation of cell shapeIEA:UniProtKB-KW
Synapse maturationIEA:Ensembl
Cellular Location
Cell membrane
Cell projection, filopodium membrane
Cell projection, axon
Cell projection, dendrite
Cell projection, dendritic spine
Basolateral cell membrane
Apicolateral cell membrane
Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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