Mouse Anti-PALM Recombinant Antibody (4E1) (CBMAB-A6310-LY)

Name: Mouse Anti-PALM Recombinant Antibody (4E1)
SKU: CBMAB-A6310-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4E1

Application

WB, ELISA

Immunogen

PALM (NP_005839, 176 a.a. ~ 284 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

paralemmin

Introduction

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Entrez Gene ID

5064

UniProt ID

O75781

Alternative Names

KIAA0270

Function

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular response to electrical stimulusIEA:Ensembl
Cytoskeleton organizationIEA:Ensembl
Negative regulation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dopamine receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneIEA:Ensembl
Regulation of cell shapeIEA:UniProtKB-KW
Synapse maturationIEA:Ensembl

Cellular Location

Cell membrane
Cell projection, filopodium membrane
Cell projection, axon
Cell projection, dendrite
Cell projection, dendritic spine
Basolateral cell membrane
Apicolateral cell membrane
Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.

Chen, X., Wang, F., Tang, J., Meng, J., & Han, Z. (2024). Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway. Respiratory Physiology & Neurobiology, 320, 104203.

Zare, M., Sadeghi, M., Ahmadpanah, J., Safari, A., & Moridi, M. (2022). Association of Palm gene mutations with structure and function of paralemmin proteins in Lori-Bakhtiari and Zel sheep Breeds. Acta Scientiarum. Animal Sciences, 45, e57287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-PALM Recombinant Antibody (7C5) (CAT#: CBMAB-P0714-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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