PALM

This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Full Name

paralemmin

Function

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular response to electrical stimulusIEA:Ensembl
Cytoskeleton organizationIEA:Ensembl
Negative regulation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dopamine receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneIEA:Ensembl
Regulation of cell shapeIEA:UniProtKB-KW
Synapse maturationIEA:Ensembl

Cellular Location

Cell membrane
Cell projection, filopodium membrane
Cell projection, axon
Cell projection, dendrite
Cell projection, dendritic spine
Basolateral cell membrane
Apicolateral cell membrane
Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.