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Mouse Anti-PALM Recombinant Antibody (7C5) (CBMAB-P0714-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
7C5
Antibody Isotype
IgG3, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
PALM (NP_005839, 176-284 aa) partial recombinant protein with GST tag. Immunogen sequence: VEKDKVTGET RVLSSTTLLP RQPLPLGIKV YEDETKVVHA VDGTAENGIH PLSSSEVDEL IHKADEVTLS EAGSTAGAAE TRGAVEGAAR TTPSRREITG VQAQPGEAT
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 176-284

Target

Full Name
paralemmin
Introduction
PALM is a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Entrez Gene ID
5064
UniProt ID
O75781
Alternative Names
Paralemmin; Paralemmin-1; KIAA0270;
Function
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular response to electrical stimulusIEA:Ensembl
Cytoskeleton organizationIEA:Ensembl
Negative regulation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of dopamine receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneIEA:Ensembl
Regulation of cell shapeIEA:UniProtKB-KW
Synapse maturationIEA:Ensembl
Cellular Location
Cell membrane
Cell projection, filopodium membrane
Cell projection, axon
Cell projection, dendrite
Cell projection, dendritic spine
Basolateral cell membrane
Apicolateral cell membrane
Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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