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Mouse Anti-PAPD7 Recombinant Antibody (2794C4a) (CBMAB-P0742-YC)

Provided herein is a Mouse monoclonal antibody against Human Poly(A) RNA Polymerase D7, Non-Canonical. The antibody can be used for immunoassay techniques, such as Dot, WB.
See all PAPD7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2794C4a
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 1% BSA, 0.05% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Poly(A) RNA Polymerase D7, Non-Canonical
Introduction
PAPD7 is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described.
Entrez Gene ID
11044
UniProt ID
Q5XG87
Alternative Names
Poly(A) RNA Polymerase D7, Non-Canonical; Topoisomerase-Related Function Protein 4-1; TRAMP-Like Complex Polyadenylate Polymerase; PAP-Associated Domain-Containing Protein 7; PAP Associated Domain Containing 7; Polymerase (DNA Directed) Sigma; Terminal Uridylyltransferase 5; DNA Polymerase Kappa; DNA Polymerase Sigma; TUTase 5; TUTase5;
Function
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317).
Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).
Biological Process
Double-strand break repair1 PublicationNAS:UniProtKB
Mitotic chromosome condensation1 PublicationNAS:UniProtKB
mRNA processingIEA:UniProtKB-KW
Negative regulation of nuclear-transcribed mRNA poly(A) tail shorteningManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of 3'-UTR-mediated mRNA stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
RNA 3' uridylationManual Assertion Based On ExperimentIMP:UniProtKB
RNA 3'-end processingManual Assertion Based On ExperimentIBA:GO_Central
RNA polyadenylationIEA:InterPro
Sister chromatid cohesionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus, nucleoplasm
Excluded from nucleolus, weak staining detected in the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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