PAPD7

PAPD7 is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described.

Full Name

Poly(A) RNA Polymerase D7, Non-Canonical

Function

Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317).
Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).

Biological Process

Double-strand break repair1 PublicationNAS:UniProtKB
Mitotic chromosome condensation1 PublicationNAS:UniProtKB
mRNA processingIEA:UniProtKB-KW
Negative regulation of nuclear-transcribed mRNA poly(A) tail shorteningManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of 3'-UTR-mediated mRNA stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
RNA 3' uridylationManual Assertion Based On ExperimentIMP:UniProtKB
RNA 3'-end processingManual Assertion Based On ExperimentIBA:GO_Central
RNA polyadenylationIEA:InterPro
Sister chromatid cohesionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus, nucleoplasm
Excluded from nucleolus, weak staining detected in the cytoplasm.