Sign in or Register
  • Home
  • PARP16
  • Mouse Anti-PARP16 Recombinant Antibody (2C8)

Mouse Anti-PARP16 Recombinant Antibody (2C8) (CBMAB-P0815-YC)

See all PARP16 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
2C8
Application
WB, FC
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Poly(ADP-Ribose) Polymerase Family Member 16
Introduction
PARP16 has ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues.
Entrez Gene ID
54956
UniProt ID
Q8N5Y8
Alternative Names
Poly(ADP-Ribose) Polymerase Family Member 16; ADP-Ribosyltransferase Diphtheria Toxin-Like 15; Poly [ADP-Ribose] Polymerase 16; C15orf30; PARP-16; ARTD15;
Function
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379).
May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912).
May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565).
May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Endoplasmic reticulum unfolded protein responseManual Assertion Based On ExperimentIMP:UniProtKB
IRE1-mediated unfolded protein responseManual Assertion Based On ExperimentIMP:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein auto-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Viral protein processingTAS:Reactome
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-287
Helical: 288-308
Lumenal: 309-322
PTM
Auto-mono-ADP-ribosylated.

Wang, J., Xu, J., Dong, Y., Su, Z., Su, H., Cheng, Q., & Liu, X. (2023). ADP‐ribose transferase PARP16 mediated‐unfolded protein response contributes to neuronal cell damage in cerebral ischemia/reperfusion. The FASEB Journal, 37(2), e22788.

Wang, J., Cheng, Q., Zhang, Y., Hong, C., Liu, J., Liu, X., & Chang, J. (2023). PARP16-Mediated stabilization of amyloid precursor protein mRNA exacerbates alzheimer’s disease pathogenesis. Aging and Disease, 14(4), 1458.

Palve, V., Knezevic, C. E., Bejan, D. S., Luo, Y., Li, X., Novakova, S., ... & Rix, U. (2022). The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors. Cell chemical biology, 29(2), 202-214.

Bejan, D. S., Sundalam, S., Jin, H., Morgan, R. K., Kirby, I. T., Siordia, I. R., ... & Cohen, M. S. (2022). Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor. Chemical Science, 13(46), 13898-13906.

Long, F., Yang, D., Wang, J., Wang, Q., Ni, T., Wei, G., ... & Liu, X. (2021). SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation. Acta pharmaceutica Sinica B, 11(5), 1261-1273.

Kunhiraman, H., Ramachandran, V., Edatt, L., & Sameer Kumar, V. B. (2020). Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2. Molecular and Cellular Biochemistry, 471, 15-27.

Yang, D., Wang, Q., Wei, G., Wu, J., Zhu, Y. C., Zhu, Q., ... & Zhu, Y. Z. (2020). Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging. Aging (Albany NY), 12(21), 21423.

Centko, R. M., Carlile, G. W., Barne, I., Patrick, B. O., Blagojevic, P., Thomas, D. Y., & Andersen, R. J. (2020). Combination of selective PARP3 and PARP16 inhibitory analogues of latonduine a corrects F508del-CFTR Trafficking. ACS omega, 5(40), 25593-25604.

Palve, V., Knezevic, C., Luo, Y., Li, X., Novakova, S., Welsh, E., ... & Rix, U. (2019). Abstract B021: PARP16 is a novel target of talazoparib which contributes to synergy with adavosertib in SCLC. Molecular Cancer Therapeutics, 18(12_Supplement), B021-B021.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PARP16 Recombinant Antibody (2C8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PARP16 Recombinant Antibody (4E2) (CAT#: CBMAB-P0816-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry