PARP16

PARP16 has ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues.

Full Name

Poly(ADP-Ribose) Polymerase Family Member 16

Function

Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379).
May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912).
May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565).
May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

Biological Process

Cellular response to leukemia inhibitory factorIEA:Ensembl
Endoplasmic reticulum unfolded protein responseManual Assertion Based On ExperimentIMP:UniProtKB
IRE1-mediated unfolded protein responseManual Assertion Based On ExperimentIMP:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein auto-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Viral protein processingTAS:Reactome

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-287
Helical: 288-308
Lumenal: 309-322

PTM

Auto-mono-ADP-ribosylated.