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Mouse Anti-PARP16 Recombinant Antibody (4E2) (CBMAB-P0816-YC)

Provided herein is a Mouse monoclonal antibody against Human Poly(ADP-Ribose) Polymerase Family Member 16. The antibody can be used for immunoassay techniques, such as FC.
See all PARP16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E2
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Poly(ADP-Ribose) Polymerase Family Member 16
Introduction
PARP16 has ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues.
Entrez Gene ID
54956
UniProt ID
Q8N5Y8
Alternative Names
Poly(ADP-Ribose) Polymerase Family Member 16; ADP-Ribosyltransferase Diphtheria Toxin-Like 15; Poly [ADP-Ribose] Polymerase 16; C15orf30; PARP-16; ARTD15;
Function
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379).
May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912).
May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565).
May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Endoplasmic reticulum unfolded protein responseManual Assertion Based On ExperimentIMP:UniProtKB
IRE1-mediated unfolded protein responseManual Assertion Based On ExperimentIMP:UniProtKB
NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein auto-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Viral protein processingTAS:Reactome
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-287
Helical: 288-308
Lumenal: 309-322
PTM
Auto-mono-ADP-ribosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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