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Mouse Anti-PARP4 Recombinant Antibody (P193-10) (CBMAB-V0238-LY)

This product is antibody recognizes PARP4. The antibody P193-10 immunoassay techniques such as: IHC-Fr, WB.
See all PARP4 antibodies
Published Data
Fig.1 Xenograft tumor sections from castrated animals after treatment with the solvent or AP21967 were subjected to immunostaining with the antibodies as indicated.
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Fig. 2 Anti-PARP immunoblotting. Antibodies reacted with both complex (260 kDa, 2.5 μg; lane 1') and 193 kDa band (VPARP, lane 2'). No signal is evident at 50 kDa.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
P193-10
Antibody Isotype
IgG2a, к
Application
IHC-Fr, WB

Basic Information

Immunogen
Proprietary immunogen
Specificity
Human
Antibody Isotype
IgG2a, к
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.1% sodium azide
Concentration
0.25 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Poly(ADP-Ribose) Polymerase Family Member 4
Introduction
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
Entrez Gene ID
143
UniProt ID
Q9UKK3
Alternative Names
Poly(ADP-Ribose) Polymerase Family Member 4; ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 1; ADP-Ribosyltransferase Diphtheria Toxin-Like 4; Von Willebrand Factor A Domain Containing 5C; PARP-Related/IalphaI-Related H5/Proline-Rich; Vault Poly(ADP-Ribose) Polymerase; 193 KDa Vault Protein; ADPRTL1; PARP-4; ARTD4; PARPL; VPARP; PH5P;
Function
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Biological Process
Cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular protein modification processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to DNA damage stimulus1 PublicationNAS:UniProtKB
DNA repairManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylation1 PublicationNAS:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to xenobiotic stimulus1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle
Also found in the nucleus, associated with mitotic spindles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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