Mouse Anti-PARVA Recombinant Antibody (1C10) (CBMAB-A4652-YC)

Name: Mouse Anti-PARVA Recombinant Antibody (1C10)
SKU: CBMAB-A4652-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C10

Application

WB, IHC, IF

Immunogen

Full length human recombinant protein of human PARVA (NP_060692) produced in HEK293T cell

Specificity

Human, Dog, Monkey

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Parvin Alpha

Introduction

PARVA is a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex an

Entrez Gene ID

Human	55742
Monkey	703481
Dog	476859

UniProt ID

Human	Q9NVD7
Monkey	A0A1D5R2Y7
Dog	J9NV14

Alternative Names

Parvin Alpha; Calponin-Like Integrin-Linked Kinase-Binding Protein; Matrix-Remodeling-Associated Protein 2; Actopaxin; CH-ILKBP; MXRA2; Matrix-Remodelling Associated 2; Alpha-Parvin;

Function

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity).
Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Actin-mediated cell contractionISS:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityISS:UniProtKB
Heterotypic cell-cell adhesionISS:UniProtKB
Outflow tract septum morphogenesisISS:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of cell shapeIEA:UniProtKB-KW
Smooth muscle cell chemotaxisISS:UniProtKB
Sprouting angiogenesisISS:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Associates with the actin cytoskeleton.

Yuan, J., Guo, L., Wang, J., Zhou, Z., & Wu, C. (2023). α-parvin controls chondrocyte column formation and regulates long bone development. Bone Research, 11(1), 46.

Ain, U., & Firdaus, H. (2022). Parvin: A hub of intracellular signalling pathways regulating cellular behaviour and disease progression. Acta Histochemica, 124(7), 151935.

Rogg, M., Maier, J. I., Van Wymersch, C., Helmstädter, M., Sammarco, A., Lindenmeyer, M., ... & Schell, C. (2022). α-Parvin defines a specific integrin adhesome to maintain the glomerular filtration barrier. Journal of the American Society of Nephrology, 33(4), 786-808.

Onetti, Y., Kälin, R. E., Pitter, B., Hou, M., Arribas, V., Glass, R., & Montanez, E. (2022). Deletion of endothelial α-parvin inhibits tumour angiogenesis, reduces tumour growth and induces tumour cell apoptosis. Angiogenesis, 25(2), 155-158.

Huang, C., Shen, Q., Song, G., He, S., & Zhou, L. (2021). Downregulation of PARVA promotes metastasis by modulating integrin-linked kinase activity and regulating MAPK/ERK and MLC2 signaling in prostate cancer. Translational Andrology and Urology, 10(2), 915.

Nicholson, L., Madawala, R., Lindsay, L., & Murphy, C. R. (2019). α-Parvin and β-parvin in the rat uterus during decidualisation and uterine receptivity. Histochemistry and Cell Biology, 151, 395-406.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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