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Mouse Anti-PARVA Recombinant Antibody (1C10) (CBMAB-A4652-YC)

Provided herein is a Mouse monoclonal antibody against Human Parvin Alpha. The antibody can be used for immunoassay techniques, such as WB, IHC, IF.
See all PARVA antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey
Clone
1C10
Antibody Isotype
IgG2a
Application
WB, IHC, IF

Basic Information

Immunogen
Full length human recombinant protein of human PARVA (NP_060692) produced in HEK293T cell
Specificity
Human, Dog, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Parvin Alpha
Introduction
PARVA is a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex an
Entrez Gene ID
Human55742
Monkey703481
Dog476859
UniProt ID
HumanQ9NVD7
MonkeyA0A1D5R2Y7
DogJ9NV14
Alternative Names
Parvin Alpha; Calponin-Like Integrin-Linked Kinase-Binding Protein; Matrix-Remodeling-Associated Protein 2; Actopaxin; CH-ILKBP; MXRA2; Matrix-Remodelling Associated 2; Alpha-Parvin;
Function
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity).
Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Actin-mediated cell contractionISS:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityISS:UniProtKB
Heterotypic cell-cell adhesionISS:UniProtKB
Outflow tract septum morphogenesisISS:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of cell shapeIEA:UniProtKB-KW
Smooth muscle cell chemotaxisISS:UniProtKB
Sprouting angiogenesisISS:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Associates with the actin cytoskeleton.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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