Human Recombinant PARVA protein, GST Tag (V2LY-0526-LY5976)

Name: Human Recombinant PARVA protein, GST Tag
SKU: V2LY-0526-LY5976
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PARVA protein, GST Tag consist of Amino Acid: 1-372 and predicts a molecular mass of 69.4 kDa.

Molecule Mass

69.4 kDa

Sequence

Amino Acid: 1-372

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>60% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Parvin Alpha

Function

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity).
Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Actin-mediated cell contractionISS:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityISS:UniProtKB
Heterotypic cell-cell adhesionISS:UniProtKB
Outflow tract septum morphogenesisISS:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of cell shapeIEA:UniProtKB-KW
Smooth muscle cell chemotaxisISS:UniProtKB
Sprouting angiogenesisISS:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Associates with the actin cytoskeleton.

Yuan, J., Guo, L., Wang, J., Zhou, Z., & Wu, C. (2023). α-parvin controls chondrocyte column formation and regulates long bone development. Bone Research, 11(1), 46.

Ain, U., & Firdaus, H. (2022). Parvin: A hub of intracellular signalling pathways regulating cellular behaviour and disease progression. Acta Histochemica, 124(7), 151935.

Rogg, M., Maier, J. I., Van Wymersch, C., Helmstädter, M., Sammarco, A., Lindenmeyer, M., ... & Schell, C. (2022). α-Parvin defines a specific integrin adhesome to maintain the glomerular filtration barrier. Journal of the American Society of Nephrology, 33(4), 786-808.

Onetti, Y., Kälin, R. E., Pitter, B., Hou, M., Arribas, V., Glass, R., & Montanez, E. (2022). Deletion of endothelial α-parvin inhibits tumour angiogenesis, reduces tumour growth and induces tumour cell apoptosis. Angiogenesis, 25(2), 155-158.

Huang, C., Shen, Q., Song, G., He, S., & Zhou, L. (2021). Downregulation of PARVA promotes metastasis by modulating integrin-linked kinase activity and regulating MAPK/ERK and MLC2 signaling in prostate cancer. Translational Andrology and Urology, 10(2), 915.

Nicholson, L., Madawala, R., Lindsay, L., & Murphy, C. R. (2019). α-Parvin and β-parvin in the rat uterus during decidualisation and uterine receptivity. Histochemistry and Cell Biology, 151, 395-406.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PARVA protein, Biotin Conjugated, GST Tag (CAT#: V2LY-0526-LY5977)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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