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Mouse Anti-PAXX Recombinant Antibody (CBWJC-4269) (CBMAB-C5626WJ)

This product is a Mouse antibody that recognizes PAXX. This antibody CBWJC-4269 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all PAXX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-4269
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PAXX, Non-Homologous End Joining Factor
Introduction
The protein encoded by this gene plays a role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair. The encoded protein may function to stabilize the Ku70/Ku80 heterodimer to facilitate the assembly and maintain the stability of the NHEJ complex. [provided by RefSeq, Jul 2016]
Entrez Gene ID
286257
UniProt ID
Q9BUH6
Alternative Names
PAXX, Non-Homologous End Joining Factor; Paralog Of XRCC4 And XLF; XRCC4-Like Small Protein; C9orf142; XLS; Chromosome 9 Open Reading Frame 142; Protein PAXX;
Function
Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800).
May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166).
Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001).
Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:30250067, PubMed:25670504).
Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27705800).
Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism (PubMed:29144403).
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Chromosome
Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation.2 Publications
Cytoplasm
(Microbial infection) Upon infection by herpesvirus 1 (HSV-1), it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
PTM
Phosphorylation may inhibit interaction with the DNA-bound XRCC5/Ku80 and XRCC6/Ku70 heterodimer (Ku complex).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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