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Mouse Anti-PBK Recombinant Antibody (CBYC-P186) (CBMAB-P0915-YC)

Provided herein is a Mouse monoclonal antibody against Human PDZ Binding Kinase. The antibody can be used for immunoassay techniques, such as ELISA, WB, IF, IHC-P.
See all PBK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P186
Antibody Isotype
IgG2b, κ
Application
ELISA, WB, IF, IHC-P

Basic Information

Immunogen
PBK (AAH15191, 1-110 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PDZ Binding Kinase
Introduction
PBK is a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis.
Entrez Gene ID
55872
UniProt ID
Q96KB5
Alternative Names
CT84; Nori-3; SPK; TOPK
Function
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Biological Process
Cellular response to UVIEA:Ensembl
Mitotic cell cycle1 PublicationNAS:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIEA:Ensembl
Negative regulation of protein phosphorylationIEA:Ensembl
Negative regulation of stress-activated MAPK cascadeIEA:Ensembl
Cellular Location
Nucleus
PTM
Phosphorylated; in a cell-cycle dependent manner at mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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