Human Recombinant PBK protein, GST Tag (V2LY-0526-LY5980)

Name: Human Recombinant PBK protein, GST Tag
SKU: V2LY-0526-LY5980
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PBK protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 68 kDa.

Molecule Mass

68 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

PDZ Binding Kinase

Function

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Biological Process

Cellular response to UVIEA:Ensembl
Mitotic cell cycle1 PublicationNAS:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIEA:Ensembl
Negative regulation of protein phosphorylationIEA:Ensembl
Negative regulation of stress-activated MAPK cascadeIEA:Ensembl

Cellular Location

Nucleus

PTM

Phosphorylated; in a cell-cycle dependent manner at mitosis.

Wu, H., Qian, J., Zhou, L., Hu, T., Zhang, Y., Wang, C., ... & Gu, C. (2024). FHND004 inhibits malignant proliferation of multiple myeloma by targeting PDZ-binding kinase in MAPK pathway. Aging (Albany NY), 16(5), 4811.

Mu, W., Xie, Y., Li, J., Yan, R., Zhang, J., Liu, Y. E., & Fan, Y. (2022). High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. World Journal of Surgical Oncology, 20(1), 22.

Miki, Y., Devi, L., Imai, Y., Minami, N., Koide, T., & Goel, S. (2020). Deletion of the PDZ-binding kinase (Pbk) gene does not affect male fertility in mice. Reproduction, Fertility and Development, 32(10), 893-902.

Mao, P., Bao, G., Wang, Y. C., Du, C. W., Yu, X., Guo, X. Y., ... & Wang, M. D. (2020). PDZ-binding kinase-dependent transcriptional regulation of CCNB2 promotes tumorigenesis and radio-resistance in glioblastoma. Translational oncology, 13(2), 287-294.

Chen, D., Cox, J., Annam, J., Weingart, M., Essien, G., Rathi, K. S., ... & Schnepp, R. W. (2020). LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase. Neoplasia, 22(6), 231-241.

Kar, A., Zhang, Y., Yacob, B. W., Saeed, J., Tompkins, K. D., Bagby, S. M., ... & Kiseljak-Vassiliades, K. (2019). Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC. Endocrine-related cancer, 26(10), 765-778.

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., ... & Asim, M. (2019). A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer. Oncogene, 38(7), 1136-1150.

Zhang, Y., Yang, X., Wang, R., & Zhang, X. (2019). Prognostic value of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) in patients with cancer. Journal of Cancer, 10(1), 131.

Diao, X., Yang, D., Chen, Y., & Liu, W. (2019). Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase. Bioscience Reports, 39(4), BSR20181692.

Kruthika, B. S., Jain, R., Arivazhagan, A., Bharath, R. D., Yasha, T. C., Kondaiah, P., & Santosh, V. (2019). Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma. Journal of neuro-oncology, 141, 315-325.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PBK, Active protein, GST Tag (CAT#: V2LY-0526-LY5981)

Human Recombinant PBK protein, His Tag (CAT#: V2LY-0526-LY5982)

PBK Matched Antibody Pair (845) (CAT#: APMAB-845LY)

Antibody Pairs

PBK Matched Antibody Pair (845) (CAT#: APMAB-845LY)

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Human Recombinant PBK, Active protein, GST Tag (CAT#: V2LY-0526-LY5981)

PBK Matched Antibody Pair (845) (CAT#: APMAB-845LY)

Mouse Anti-PBK Monoclonal Antibody (3F7) (CAT#: CBMAB-1440-YC)

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Mouse Anti-PBK Recombinant Antibody (2D2) (CAT#: CBMAB-A6371-LY)

Human Recombinant PBK protein, His Tag (CAT#: V2LY-0526-LY5982)

Mouse Anti-PBK Recombinant Antibody (CBYC-P185) (CAT#: CBMAB-P0914-YC)

Mouse Anti-PBK Recombinant Antibody (4A10) (CAT#: CBMAB-P0912-YC)

Isotype control

For research use only. Not intended for any clinical use.

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