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Rabbit Anti-PBRM1 Recombinant Antibody (CB-39-2C3) (CBMAB-BT066LY)

The product is antibody recognizes PBRM1. The antibody CB-39-2C3 immunoassay techniques such as: WB, IP, IHC, ICC.
See all PBRM1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CB-39-2C3
Antibody Isotype
IgG
Application
WB, IP, IHC, ICC

Basic Information

Immunogen
aa 1-293
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
polybromo 1
Introduction
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Entrez Gene ID
Human55193
Mouse66923
UniProt ID
HumanQ86U86
MouseQ8BSQ9
Alternative Names
Polybromo 1; BRG1-Associated Factor 180; Polybromo-1D; BAF180; PB1; Protein Polybromo-1; HPB1;
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.
Biological Process
Chromatin remodelingManual Assertion Based On ExperimentTAS:UniProtKB
Mitotic cell cycleManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell differentiation1 PublicationIC:ComplexPortal
Positive regulation of double-strand break repair1 PublicationIC:ComplexPortal
Positive regulation of myoblast differentiation1 PublicationIC:ComplexPortal
Positive regulation of T cell differentiation1 PublicationIC:ComplexPortal
Regulation of G0 to G1 transition1 PublicationIC:ComplexPortal
Regulation of G1/S transition of mitotic cell cycle1 PublicationIC:ComplexPortal
Regulation of mitotic metaphase/anaphase transition1 PublicationIC:ComplexPortal
Regulation of nucleotide-excision repair1 PublicationIC:ComplexPortal
Regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Cellular Location
Nucleus
Involvement in disease
Renal cell carcinoma (RCC):
Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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