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Mouse Anti-PCNP Recombinant Antibody (2707C2a) (CBMAB-P1080-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2707C2a
Antibody Isotype
IgG1
Application
Dot

Basic Information

Immunogen
Recombinant human Pest Proteolytic Signal Containing Nuclear Protein (Pcnp)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PEST Proteolytic Signal Containing Nuclear Protein
Introduction
PCNP has ubiquitous expression in ovary (RPKM 78.0), thyroid (RPKM 65.5) and 25 other tissues.
Entrez Gene ID
57092
UniProt ID
Q8WW12
Alternative Names
PEST Proteolytic Signal Containing Nuclear Protein; PEST-Containing Nuclear Protein;
Function
May be involved in cell cycle regulation.
Biological Process
Cell cycleIEA:UniProtKB-KW
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein ubiquitinationManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.
N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.
More Infomation

Yan, D., Liu, Y., Zhang, S., Fang, B., Zhao, F., & Yang, Z. (2024). PCNP: A RoCEv2 congestion control using precise CNP. Computer Networks, 247, 110453.

Zhang, L., Guo, D., Shen, J., Zheng, Y., Zhai, J., Li, R., ... & Zhang, B. (2023). Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation. Frontiers in Oncology, 12, 1072276.

Chen, Y. G., Liu, H. X., Hong, Y., Dong, P. Z., Liu, S. Y., Gao, Y. R., ... & Ji, X. Y. (2022). PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer. International Journal of Biological Sciences, 18(9), 3605.

Xu, T., Wu, K., Shi, J., Ji, L., Song, X., Tao, G., ... & Jiang, B. (2022). LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP. Cell death discovery, 8(1), 228.

Caruso, A. M., & Schlamb, C. (2021). PCNP: A new era in shaping health policy. Journal of the American Association of Nurse Practitioners, 33(11), 857-861.

Han, Z. P., Yang, Y., Chen, H. Y., Zhong, M. Y., & Zhuang, G. H. (2021). TIPE2 and PCNP expression abnormalities in peripheral blood mononuclear cells associated with disease activity in rheumatoid arthritis: a meta-analysis. European Review for Medical & Pharmacological Sciences, 25(3).

Dong, P., Fu, H., Chen, L., Zhang, S., Zhang, X., Li, H., ... & Ji, X. (2020). PCNP promotes ovarian cancer progression by accelerating β‐catenin nuclear accumulation and triggering EMT transition. Journal of Cellular and Molecular Medicine, 24(14), 8221-8235.

Afzal, A., Sarfraz, M., Li, G. L., Ji, S. P., Duan, S. F., Khan, N. H., ... & Ji, X. Y. (2019). Taking a holistic view of PEST‐containing nuclear protein (PCNP) in cancer biology. Cancer Medicine, 8(14), 6335-6343.

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For research use only. Not intended for any clinical use.

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