Mouse Anti-PCNP Recombinant Antibody (F-1) (CBMAB-P1081-YC)

Name: Mouse Anti-PCNP Recombinant Antibody (F-1)
SKU: CBMAB-P1081-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

F-1

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PEST Proteolytic Signal Containing Nuclear Protein

Introduction

PCNP has ubiquitous expression in ovary (RPKM 78.0), thyroid (RPKM 65.5) and 25 other tissues.

Entrez Gene ID

57092

UniProt ID

Q8WW12

Alternative Names

PEST Proteolytic Signal Containing Nuclear Protein; PEST-Containing Nuclear Protein;

Function

May be involved in cell cycle regulation.

Biological Process

Cell cycleIEA:UniProtKB-KW
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Protein ubiquitinationManual Assertion Based On ExperimentIDA:HGNC-UCL

Cellular Location

Nucleus

PTM

Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.
N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.

Yan, D., Liu, Y., Zhang, S., Fang, B., Zhao, F., & Yang, Z. (2024). PCNP: A RoCEv2 congestion control using precise CNP. Computer Networks, 247, 110453.

Zhang, L., Guo, D., Shen, J., Zheng, Y., Zhai, J., Li, R., ... & Zhang, B. (2023). Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation. Frontiers in Oncology, 12, 1072276.

Chen, Y. G., Liu, H. X., Hong, Y., Dong, P. Z., Liu, S. Y., Gao, Y. R., ... & Ji, X. Y. (2022). PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer. International Journal of Biological Sciences, 18(9), 3605.

Xu, T., Wu, K., Shi, J., Ji, L., Song, X., Tao, G., ... & Jiang, B. (2022). LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP. Cell death discovery, 8(1), 228.

Caruso, A. M., & Schlamb, C. (2021). PCNP: A new era in shaping health policy. Journal of the American Association of Nurse Practitioners, 33(11), 857-861.

Han, Z. P., Yang, Y., Chen, H. Y., Zhong, M. Y., & Zhuang, G. H. (2021). TIPE2 and PCNP expression abnormalities in peripheral blood mononuclear cells associated with disease activity in rheumatoid arthritis: a meta-analysis. European Review for Medical & Pharmacological Sciences, 25(3).

Dong, P., Fu, H., Chen, L., Zhang, S., Zhang, X., Li, H., ... & Ji, X. (2020). PCNP promotes ovarian cancer progression by accelerating β‐catenin nuclear accumulation and triggering EMT transition. Journal of Cellular and Molecular Medicine, 24(14), 8221-8235.

Afzal, A., Sarfraz, M., Li, G. L., Ji, S. P., Duan, S. F., Khan, N. H., ... & Ji, X. Y. (2019). Taking a holistic view of PEST‐containing nuclear protein (PCNP) in cancer biology. Cancer Medicine, 8(14), 6335-6343.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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