Mouse Anti-PDE1B Recombinant Antibody (4F9) (CBMAB-P1192-YC)

Name: Mouse Anti-PDE1B Recombinant Antibody (4F9)
SKU: CBMAB-P1192-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4F9

Application

ELISA, WB

Immunogen

PDE1B (AAH32226, 437-536 aa) partial recombinant protein with GST tag. Immunogen sequence: TDVAEKSVQP LADEDSKSKN QPSFQWRQPS LDVEVGDPNP DVVSFRSTWV KRIQENKQKW KERAASGITN QMSIDELSPC EEEAPPSPAE DEHNQNGNLD

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosphodiesterase 1B, calmodulin-dependent

Introduction

PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Entrez Gene ID

5153

UniProt ID

Q01064

Alternative Names

Phosphodiesterase 1B; Phosphodiesterase 1B, Calmodulin-Dependent; 3 KDa Cam-PDE; EC 3.1.4.17; Cam-PDE 1B; PDES1B; PDE1B1; Presumed 63kDa Form Of The Type 1 Cyclic Nucleotide Phosphodiesterase Family Known As PDE1B;

Function

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8855339, PubMed:9419816, PubMed:15260978).
Has a preference for cGMP as a substrate (PubMed:9419816).

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorIEA:Ensembl
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of neurotransmitter levelsIEA:Ensembl
Response to amphetamineIEA:Ensembl
Serotonin metabolic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl

Cellular Location

Cytoplasm, cytosol

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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