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PDE1B

PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Full Name

phosphodiesterase 1B, calmodulin-dependent

Function

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8855339, PubMed:9419816, PubMed:15260978).
Has a preference for cGMP as a substrate (PubMed:9419816).

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorIEA:Ensembl
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of neurotransmitter levelsIEA:Ensembl
Response to amphetamineIEA:Ensembl
Serotonin metabolic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl

Cellular Location

Cytoplasm, cytosol

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Anti-PDE1B antibodies

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Mouse Anti-PDE1B Recombinant Antibody (5B6) (CBMAB-A6517-LY)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5B6

Application*: WB, E

Mouse Anti-PDE1B Recombinant Antibody (6E4) (CBMAB-P1195-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 6E4

Application*: F, IF, P, WB

Mouse Anti-PDE1B Recombinant Antibody (6B9) (CBMAB-P1194-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog, Rat, Monkey

Clone: 6B9

Application*: WB, IF, F

Mouse Anti-PDE1B Recombinant Antibody (5C4A3) (CBMAB-P1193-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5C4A3

Application*: E, F, IH, P, WB

Mouse Anti-PDE1B Recombinant Antibody (4F9) (CBMAB-P1192-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 4F9

Application*: E, WB

Mouse Anti-PDE1B Recombinant Antibody (4E8) (CBMAB-P1191-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4E8

Application*: E, WB

Mouse Anti-PDE1B Recombinant Antibody (1D6) (CBMAB-P1190-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1D6

Application*: F, WB

Mouse Anti-PDE1B Recombinant Antibody (14i206) (CBMAB-P1189-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 14i206

Application*: E, F, IH, WB

Mouse Anti-PDE1B Recombinant Antibody (10B10B12) (CBMAB-P1188-YC)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 10B10B12

Application*: E, F, WB

Human Recombinant PDE1B protein, GST Tag (V2LY-0526-LY6026)

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Target: PDE1B

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-536

Tag: GST Tag

Human Recombinant PDE1B, Active protein, GST Tag (V2LY-0526-LY6025)

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Target: PDE1B

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Mouse Anti-PDE1B Recombinant Antibody (CBT2179) (V2LY-0625-LY925)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2179

Application*: IH, F

Mouse Anti-PDE1B Recombinant Antibody (CBT3301) (V2LY-0625-LY924)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBT3301

Application*: F

Mouse Anti-PDE1B Recombinant Antibody (CBT3512) (V2LY-0625-LY923)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey

Clone: CBT3512

Application*: F

Mouse Anti-PDE1B Recombinant Antibody (CBT2214) (V2LY-0625-LY922)

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Target: PDE1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBT2214

Application*: IH, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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