PDE1B
PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Full Name
phosphodiesterase 1B, calmodulin-dependent
Function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8855339, PubMed:9419816, PubMed:15260978).
Has a preference for cGMP as a substrate (PubMed:9419816).
Has a preference for cGMP as a substrate (PubMed:9419816).
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorIEA:Ensembl
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of neurotransmitter levelsIEA:Ensembl
Response to amphetamineIEA:Ensembl
Serotonin metabolic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorIEA:Ensembl
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of neurotransmitter levelsIEA:Ensembl
Response to amphetamineIEA:Ensembl
Serotonin metabolic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
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Anti-PDE1B antibodies
+ Filters

Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B6
Application*: WB, E
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6E4
Application*: F, IF, P, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: 6B9
Application*: WB, IF, F
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C4A3
Application*: E, F, IH, P, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4F9
Application*: E, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E8
Application*: E, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D6
Application*: F, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i206
Application*: E, F, IH, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 10B10B12
Application*: E, F, WB
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2179
Application*: IH, F
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBT3301
Application*: F
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT3512
Application*: F
Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT2214
Application*: IH, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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