PDE1B

PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Full Name
phosphodiesterase 1B, calmodulin-dependent
Function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8855339, PubMed:9419816, PubMed:15260978).
Has a preference for cGMP as a substrate (PubMed:9419816).
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorIEA:Ensembl
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of neurotransmitter levelsIEA:Ensembl
Response to amphetamineIEA:Ensembl
Serotonin metabolic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
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Anti-PDE1B antibodies

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Mouse Anti-PDE1B Recombinant Antibody (5B6) (CBMAB-A6517-LY)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5B6
Application*: WB, E
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (6E4) (CBMAB-P1195-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6E4
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (6B9) (CBMAB-P1194-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: 6B9
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (5C4A3) (CBMAB-P1193-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C4A3
Application*: E, F, IH, P, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (4F9) (CBMAB-P1192-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4F9
Application*: E, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (4E8) (CBMAB-P1191-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E8
Application*: E, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (1D6) (CBMAB-P1190-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D6
Application*: F, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (14i206) (CBMAB-P1189-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i206
Application*: E, F, IH, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (10B10B12) (CBMAB-P1188-YC)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 10B10B12
Application*: E, F, WB
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (CBT2179) (V2LY-0625-LY925)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2179
Application*: IH, F
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (CBT3301) (V2LY-0625-LY924)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBT3301
Application*: F
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (CBT3512) (V2LY-0625-LY923)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT3512
Application*: F
Datasheet SDS

Mouse Anti-PDE1B Recombinant Antibody (CBT2214) (V2LY-0625-LY922)

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Target: PDE1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT2214
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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