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Mouse Anti-PDE1B Recombinant Antibody (6B9) (CBMAB-P1194-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 1B. The antibody can be used for immunoassay techniques, such as WB, IF, FC.
See all PDE1B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey
Clone
6B9
Antibody Isotype
IgG2b
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human PDE1B(NP_000915) produced in HEK293T cell
Specificity
Human, Dog, Rat, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol and 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 1B, calmodulin-dependent
Introduction
PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
Human5153
Dog100856025
Rat29691
Monkey705920
UniProt ID
HumanQ01064
DogJ9NYV0
RatQ01066
MonkeyA0A1D5Q8U6
Alternative Names
Phosphodiesterase 1B; Phosphodiesterase 1B, Calmodulin-Dependent; 3 KDa Cam-PDE; EC 3.1.4.17; Cam-PDE 1B; PDES1B; PDE1B1; Presumed 63kDa Form Of The Type 1 Cyclic Nucleotide Phosphodiesterase Family Known As PDE1B;
Function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8855339, PubMed:9419816, PubMed:15260978).
Has a preference for cGMP as a substrate (PubMed:9419816).
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to granulocyte macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to macrophage colony-stimulating factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Locomotory behaviorIEA:Ensembl
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of neurotransmitter levelsIEA:Ensembl
Response to amphetamineIEA:Ensembl
Serotonin metabolic processIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Visual learningIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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