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Rat Anti-PDE4DIP Recombinant Antibody (CBFYH-3627) (CBMAB-H4185-FY)

This product is rat antibody that recognizes PDE4DIP. The antibody CBFYH-3627 can be used for immunoassay techniques such as: FC, FuncS.
See all PDE4DIP antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYH-3627
Antibody Isotype
IgG2a
Application
FC, FuncS

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphodiesterase 4D Interacting Protein
Introduction
The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
83679
UniProt ID
Q80YT7
Alternative Names
Phosphodiesterase 4D Interacting Protein; Cardiomyopathy-Associated Protein 2; Myomegalin; CMYA2; MMGL; Myomegalin/Phosphodiesterase 4D Interacting Protein Variant 8
Function
Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).
Isoform 13
Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697).
In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570).
In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).
Biological Process
Astral microtubule organizationIMP:UniProtKB
Positive regulation of microtubule nucleationIMP:UniProtKB
Protein-containing complex assemblyBy SimilarityISS:UniProtKB
Regulation of Golgi organizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Isoform 13
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton
Golgi apparatus
Associated with the microtubule network at the growing distal tip of microtubules (PubMed:29162697).
Targeting to the Golgi apparatus requires AKAP9 (PubMed:25217626).
Involvement in disease
A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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