PDE4DIP

The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Full Name

Phosphodiesterase 4D Interacting Protein

Function

Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).
Isoform 13
Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697).
In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570).
In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).

Biological Process

Astral microtubule organizationIMP:UniProtKB
Positive regulation of microtubule nucleationIMP:UniProtKB
Protein-containing complex assemblyBy SimilarityISS:UniProtKB
Regulation of Golgi organizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Isoform 13
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton
Golgi apparatus
Associated with the microtubule network at the growing distal tip of microtubules (PubMed:29162697).
Targeting to the Golgi apparatus requires AKAP9 (PubMed:25217626).

Involvement in disease

A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.