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Mouse Anti-PDIA3 Recombinant Antibody (3E1) (CBMAB-P1293-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Disulfide Isomerase Family A Member 3. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all PDIA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E1
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids PDIA3(NP_005304) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Disulfide Isomerase Family A Member 3
Introduction
PDIA3 is a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates.
Entrez Gene ID
2923
UniProt ID
P30101
Alternative Names
Protein Disulfide Isomerase Family A Member 3; Endoplasmic Reticulum Resident Protein 60; Endoplasmic Reticulum Resident Protein 57; Protein Disulfide Isomerase-Associated 3; Glucose Regulated Protein, 58kDa; 58 KDa Glucose-Regulated Protein; Disulfide Isomerase ER-60; 58 KDa Microsomal Protein; ER Protein 57; ER Protein 60; EC 5.3.4.1; ERp60; GRP58; ERp57; P58;
Function
Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (PubMed:7487104, PubMed:27897272).
Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:27897272).
Association with calcitriol does not affect its enzymatic activity (PubMed:27897272).
Biological Process
Cellular response to interleukin-7IEA:Ensembl
Peptide antigen assembly with MHC class I protein complexManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein folding in endoplasmic reticulumManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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