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PDIA3

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

Full Name

Protein Disulfide Isomerase Family A Member 3

Function

Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (PubMed:7487104, PubMed:27897272).
Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:27897272).
Association with calcitriol does not affect its enzymatic activity (PubMed:27897272).

Biological Process

Cellular response to interleukin-7IEA:Ensembl
Peptide antigen assembly with MHC class I protein complexManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein folding in endoplasmic reticulumManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).

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Anti-PDIA3 antibodies

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Mouse Anti-PDIA3 Recombinant Antibody (4F9) (CBMAB-AP3060LY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4F9

Application*: ICC/IF, WB

Mouse Anti-PDIA3 Recombinant Antibody (CBYC-P264) (CBMAB-P1296-YC)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P264

Application*: WB, IC, P, C, E

Mouse Anti-PDIA3 Recombinant Antibody (ERP57) (CBMAB-P1295-YC)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: ERP57

Application*: IH, P, IP, WB

Mouse Anti-PDIA3 Recombinant Antibody (3H5) (CBMAB-P1294-YC)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3H5

Application*: P, WB

Mouse Anti-PDIA3 Recombinant Antibody (3E1) (CBMAB-P1293-YC)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3E1

Application*: P, WB

Mouse Anti-PDIA3 (AA 25-505) Recombinant Antibody (CBFYE-1580) (CBMAB-E2236-FY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CBFYE-1580

Application*: WB, F, E, IF

Mouse Anti-PDIA3 Recombinant Antibody (CBFYE-1579) (CBMAB-E2235-FY)

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Target: PDIA3

Host: Mouse

Specificity: Human

Clone: CBFYE-1579

Application*: WB, IP, IF

Mouse Anti-PDIA3 Recombinant Antibody (CBFYE-1578) (CBMAB-E2234-FY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1578

Application*: WB, IH, IF

Mouse Anti-PDIA3 (AA 140-505) Recombinant Antibody (CBFYE-1576) (CBMAB-E2232-FY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYE-1576

Application*: WB, IH

Mouse Anti-PDIA3 Recombinant Antibody (CBFYE-1575) (CBMAB-E2231-FY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-1575

Application*: WB, IH

Mouse Anti-PDIA3 Recombinant Antibody (CBFYE-1574) (CBMAB-E2229-FY)

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Target: PDIA3

Host: Mouse

Specificity: Cattle, Dog, Guinea Pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat

Clone: CBFYE-1574

Application*: IH, IP, WB

Mouse Anti-PDIA3 Recombinant Antibody (CBFYE-0103) (CBMAB-E0211-FY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-0103

Application*: WB, IF

Mouse Anti-PDIA3 Recombinant Antibody (Map.ERP57) (CBMAB-E0411-FY)

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Target: PDIA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Rabbit, Guinea Pig, Monkey, Pig, Hamster

Clone: Map.ERP57

Application*: WB, P, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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