Mouse Anti-PDIA3 Recombinant Antibody (3H5) (CBMAB-P1294-YC)

Name: Mouse Anti-PDIA3 Recombinant Antibody (3H5)
SKU: CBMAB-P1294-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3H5

Application

IHC-P, WB

Immunogen

Human recombinant protein fragment corresponding to amino acids 140-505 of human PDIA3(NP_005304) produced in E. coli.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 140-505

More Infomation

Target

Full Name

Protein Disulfide Isomerase Family A Member 3

Introduction

PDIA3 is a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates.

Entrez Gene ID

2923

UniProt ID

P30101

Alternative Names

Protein Disulfide Isomerase Family A Member 3; Endoplasmic Reticulum Resident Protein 60; Endoplasmic Reticulum Resident Protein 57; Protein Disulfide Isomerase-Associated 3; Glucose Regulated Protein, 58kDa; 58 KDa Glucose-Regulated Protein; Disulfide Isomerase ER-60; 58 KDa Microsomal Protein; ER Protein 57; ER Protein 60; EC 5.3.4.1; ERp60; GRP58; ERp57; P58;

Function

Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (PubMed:7487104, PubMed:27897272).
Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:27897272).
Association with calcitriol does not affect its enzymatic activity (PubMed:27897272).

Biological Process

Cellular response to interleukin-7IEA:Ensembl
Peptide antigen assembly with MHC class I protein complexManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein folding in endoplasmic reticulumManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum lumen
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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