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Mouse Anti-PEAR1 Recombinant Antibody (12K158) (CBMAB-P1400-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
12K158
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Saline, 0.5% BSA, 0.1% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 21-754

Target

Full Name
Platelet Endothelial Aggregation Receptor 1
Introduction
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation.
Entrez Gene ID
375033
UniProt ID
Q5VY43
Alternative Names
Platelet Endothelial Aggregation Receptor 1; Multiple Epidermal Growth Factor-Like Domains Protein 12; Multiple EGF-Like Domains Protein 12; Multiple EGF-Like-Domains 12; MEGF12; HPEAR1; JEDI;
Function
When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
Biological Process
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Platelet aggregationIEA:Ensembl
Protein kinase B signalingIEA:Ensembl
Recognition of apoptotic cellIEA:Ensembl
Cellular Location
Cell membrane
Detected on the cell surface in resting platelets.
Topology
Extracellular: 21-755
Helical: 756-776
Cytoplasmic: 777-1037
PTM
Phosphorylated in the intracellular domain on tyrosine residues (By similarity).
Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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