Mouse Anti-PEAR1 Recombinant Antibody (12K158) (CBMAB-P1400-YC)

Name: Mouse Anti-PEAR1 Recombinant Antibody (12K158)
SKU: CBMAB-P1400-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

12K158

Application

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Saline, 0.5% BSA, 0.1% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 21-754

More Infomation

Target

Full Name

Platelet Endothelial Aggregation Receptor 1

Introduction

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation.

Entrez Gene ID

375033

UniProt ID

Q5VY43

Alternative Names

Platelet Endothelial Aggregation Receptor 1; Multiple Epidermal Growth Factor-Like Domains Protein 12; Multiple EGF-Like Domains Protein 12; Multiple EGF-Like-Domains 12; MEGF12; HPEAR1; JEDI;

Function

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.

Biological Process

Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Platelet aggregationIEA:Ensembl
Protein kinase B signalingIEA:Ensembl
Recognition of apoptotic cellIEA:Ensembl

Cellular Location

Cell membrane
Detected on the cell surface in resting platelets.

Topology

Extracellular: 21-755
Helical: 756-776
Cytoplasmic: 777-1037

PTM

Phosphorylated in the intracellular domain on tyrosine residues (By similarity).
Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PEAR1 Recombinant Antibody (CBYC-P284) (CAT#: CBMAB-P1401-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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