PEAR1

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation.

Full Name

Platelet Endothelial Aggregation Receptor 1

Function

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.

Biological Process

Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Platelet aggregationIEA:Ensembl
Protein kinase B signalingIEA:Ensembl
Recognition of apoptotic cellIEA:Ensembl

Cellular Location

Cell membrane
Detected on the cell surface in resting platelets.

Topology

Extracellular: 21-755
Helical: 756-776
Cytoplasmic: 777-1037

PTM

Phosphorylated in the intracellular domain on tyrosine residues (By similarity).
Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.

Anti-PEAR1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-PEAR1 Recombinant Antibody (CBYC-P284) (CBMAB-P1401-YC)

Datasheet

SDS

Target: PEAR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-P284

Application*: F

Mouse Anti-PEAR1 Recombinant Antibody (12K158) (CBMAB-P1400-YC)

Datasheet

SDS

Target: PEAR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 12K158

Application*: F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)