PEAR1

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation.
Full Name
Platelet Endothelial Aggregation Receptor 1
Function
When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
Biological Process
Phosphatidylinositol 3-kinase signalingIEA:Ensembl
Platelet aggregationIEA:Ensembl
Protein kinase B signalingIEA:Ensembl
Recognition of apoptotic cellIEA:Ensembl
Cellular Location
Cell membrane
Detected on the cell surface in resting platelets.
Topology
Extracellular: 21-755
Helical: 756-776
Cytoplasmic: 777-1037
PTM
Phosphorylated in the intracellular domain on tyrosine residues (By similarity).
Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.
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Anti-PEAR1 antibodies

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Mouse Anti-PEAR1 Recombinant Antibody (CBYC-P284) (CBMAB-P1401-YC)

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Target: PEAR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-P284
Application*: F
Datasheet SDS

Mouse Anti-PEAR1 Recombinant Antibody (12K158) (CBMAB-P1400-YC)

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Target: PEAR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12K158
Application*: F
Datasheet SDS

Rat Recombinant PEAR1 protein, His Tag (V2LY-0526-LY9552)

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Target: PEAR1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-752
Tag: His Tag
Datasheet SDS

Rabbit Recombinant PEAR1 protein, ECD, His Tag (V2LY-0526-LY9142)

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Target: PEAR1
Expressed Host: CHO cells
Sequence: Amino Acid: 21-755
Tag: His Tag
Datasheet SDS

Cynomolgus, Rhesus Recombinant PEAR1 protein, ECD, His Tag (V2LY-0526-LY1737)

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Target: PEAR1
Expressed Host: CHO cells
Sequence: Amino Acid: 21-755
Tag: His Tag
Datasheet SDS

Canine Recombinant PEAR1 protein, ECD, His Tag (V2LY-0526-LY1313)

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Target: PEAR1
Expressed Host: CHO cells
Sequence: Amino Acid: 20-754
Tag: His Tag
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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