Mouse Anti-PF4 Recombinant Antibody (170106) (CBMAB-C0420-LY)

platelet factor 4

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

Platelet Factor 4; Chemokine (C-X-C Motif) Ligand 4; C-X-C Motif Chemokine 4; Oncostatin-A; Iroplact; CXCL4; SCYB4; PF-4;

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to protozoanManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Killing of cells of another organismIDA:UniProtKB
Leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of MHC class II biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB

Secreted