PF4

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990 [PubMed 1695112]).[supplied by OMIM

platelet factor 4

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to protozoanManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Killing of cells of another organismIDA:UniProtKB
Leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of MHC class II biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB

Secreted