PF4
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990 [PubMed 1695112]).[supplied by OMIM
Full Name
platelet factor 4
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to protozoanManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Killing of cells of another organismIDA:UniProtKB
Leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of MHC class II biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to protozoanManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Killing of cells of another organismIDA:UniProtKB
Leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of MHC class II biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
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Anti-PF4 antibodies
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CompareTarget: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: KKO
Application*: E, WB
Target: PF4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0210-14M15
Application*: WB, P
Target: PF4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L318
Application*: WB
Target: PF4
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 140910
Application*: WB, EC
Target: PF4
Expressed Host: E. coli
Sequence: Amino Acid: 30-105
Tag: His Tag
Target: PF4
Expressed Host: E. coli
Sequence: Amino Acid: 32-101
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNC-679
Application*: FC
Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-678
Application*: E, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L317
Application*: WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBCNC-100
Application*: E, ICC, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-2369
Application*: E, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2352
Application*: E, IP, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2374
Application*: WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0986
Application*: IS
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0985
Application*: EC
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: RTO
Application*: WB, E, P, F, IC, IF
Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: D-7
Application*: WB, IP, IF, E
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7H2
Application*: F
Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 197.2
Application*: E, F, IC, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 196.8
Application*: E
Target: PF4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-3034
Application*: WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0331
Application*: WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 170131
Application*: EC
Target: PF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F6
Application*: E, IP, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11N29
Application*: WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 170138
Application*: WB, IS, MC
Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 170106
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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