PF4

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990 [PubMed 1695112]).[supplied by OMIM
Full Name
platelet factor 4
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to protozoanManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Killing of cells of another organismIDA:UniProtKB
Leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of MHC class II biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
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Anti-PF4 antibodies

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Mouse Anti-PF4 Recombinant Antibody (KKO) (CBMAB-P1497-YC)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: KKO
Application*: E, WB
Datasheet SDS

Rat Anti-PF4 Recombinant Antibody (RM0210-14M15) (CBMAB-C12209-LY)

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Target: PF4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0210-14M15
Application*: WB, P
Datasheet SDS

Rat Anti-PF4 Recombinant Antibody (14L318) (CBMAB-C3165-LY)

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Target: PF4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L318
Application*: WB
Datasheet SDS

Rat Anti-PF4 Recombinant Antibody (140910) (CBMAB-C0324-LY)

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Target: PF4
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 140910
Application*: WB, EC
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBCNC-679) (CBMAB-C4073-CN)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNC-679
Application*: FC
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBCNC-678) (CBMAB-C4072-CN)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-678
Application*: E, WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (14L317) (CBMAB-C4071-CN)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L317
Application*: WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBCNC-100) (CBMAB-C0995-CN)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBCNC-100
Application*: E, ICC, WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBWJC-2369) (CBMAB-C3328WJ)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-2369
Application*: E, WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBYY-C2352) (CBMAB-C3790-YY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2352
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBXC-2374) (CBMAB-C3930-CQ)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2374
Application*: WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBXC-0986) (CBMAB-C1248-CQ)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0986
Application*: IS
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBXC-0985) (CBMAB-C1247-CQ)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0985
Application*: EC
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (RTO) (CBMAB-P1498-YC)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: RTO
Application*: WB, E, P, F, IC, IF
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (D-7) (CBMAB-P1495-YC)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: D-7
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (7H2) (CBMAB-P1494-YC)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7H2
Application*: F
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (197.2) (CBMAB-P1493-YC)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 197.2
Application*: E, F, IC, WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (196.8) (CBMAB-P1492-YC)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 196.8
Application*: E
Datasheet SDS

Rat Anti-PF4 Recombinant Antibody (CBFYC-3034) (CBMAB-C3111-FY)

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Target: PF4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-3034
Application*: WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (CBFYC-0331) (CBMAB-C0369-FY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0331
Application*: WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (170131) (CBMAB-C9445-LY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 170131
Application*: EC
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (3F6) (CBMAB-C6058-LY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F6
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (11N29) (CBMAB-C2547-LY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11N29
Application*: WB
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (170138) (CBMAB-C0421-LY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 170138
Application*: WB, IS, MC
Datasheet SDS

Mouse Anti-PF4 Recombinant Antibody (170106) (CBMAB-C0420-LY)

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Target: PF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 170106
Application*: WB
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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