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Rabbit Anti-PFKFB2 Recombinant Antibody (D5I5F) (CBMAB-CP1937-LY)

The product is antibody recognizes PFKFB2. The antibody D5I5F immunoassay techniques such as: WB,IP,IF (ICC).
See all PFKFB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D5I5F
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val82 within the 6-phosphofructo-2-kinase domain of human PFKFB2 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2
Introduction
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human5208
Monkey693509
UniProt ID
HumanO60825
MonkeyF6XIF5
Alternative Names
6-Phosphofructo-2-Kinase/Fructose-2;6-Biphosphatase 2; PF-2-K/Fru-2;6-P2ase 2; PFK/FBPase 2; -Phosphofructo-2-Kinase/Fructose-2;6-Bisphosphatase 2; Fructose-2;6-Bisphosphatase; Cardiac Isozyme; PF-2-K/Fru-2;6-P2ASE Heart-Type Isozyme; PF-2-K/Fru-2;6-P2ase Heart-Type Isozyme; PFKFB; Cardiac; PFK-2/FBPase-2;
Function
Synthesis and degradation of fructose 2,6-bisphosphate.
Biological Process
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Glucose catabolic processIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Lactate metabolic processIEA:Ensembl
Positive regulation of glucokinase activityIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Response to glucoseIEA:Ensembl
Cellular Location
cytosol
nucleoplasm
PTM
Phosphorylation by AMPK stimulates activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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