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PFKFB2

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2

Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Biological Process

Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Glucose catabolic processIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Lactate metabolic processIEA:Ensembl
Positive regulation of glucokinase activityIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Response to glucoseIEA:Ensembl

Cellular Location

cytosol
nucleoplasm

PTM

Phosphorylation by AMPK stimulates activity.

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Anti-PFKFB2 antibodies

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Rabbit Anti-PFKFB2 Recombinant Antibody (D7G5R) (CBMAB-CP1938-LY)

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Target: PFKFB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D7G5R

Application*: WB, IP, IF (IC)

Rabbit Anti-PFKFB2 Recombinant Antibody (D7G5R)

Rabbit Anti-PFKFB2 Recombinant Antibody (D5I5F) (CBMAB-CP1937-LY)

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Target: PFKFB2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D5I5F

Application*: WB, IP, IF (IC)

Rabbit Anti-PFKFB2 Recombinant Antibody (D5I5F)

Human PFKFB2 ELISA Kit (V2LY-0626-LY3680)

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Target: PFKFB2

Sensitivity: 0.017 ng/mL

Detection Range: 0.05-15 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human PFKFB2 ELISA Kit

Human Recombinant PFKFB2/PFK2 protein, GST Tag (V2LY-0526-LY6123)

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Target: PFKFB2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Human Recombinant PFKFB2/PFK2 protein, GST Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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