PFKFB2

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2

Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Biological Process

Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Glucose catabolic processIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Lactate metabolic processIEA:Ensembl
Positive regulation of glucokinase activityIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Response to glucoseIEA:Ensembl

Cellular Location

cytosol
nucleoplasm

PTM

Phosphorylation by AMPK stimulates activity.