Rabbit Anti-PFKFB2 Recombinant Antibody (D7G5R) (CBMAB-CP1938-LY)

Name: Rabbit Anti-PFKFB2 Recombinant Antibody (D7G5R)
SKU: CBMAB-CP1938-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

D7G5R

Application

WB, IP, IF (ICC)

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro454 within the fructose-2,6-biphosphatase region of human PFKFB2 protein.

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2

Introduction

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	5208
Monkey	693509

UniProt ID

Human	O60825
Monkey	F6XIF5

Alternative Names

6-Phosphofructo-2-Kinase/Fructose-2;6-Biphosphatase 2; PF-2-K/Fru-2;6-P2ase 2; PFK/FBPase 2; -Phosphofructo-2-Kinase/Fructose-2;6-Bisphosphatase 2; Fructose-2;6-Bisphosphatase; Cardiac Isozyme; PF-2-K/Fru-2;6-P2ASE Heart-Type Isozyme; PF-2-K/Fru-2;6-P2ase Heart-Type Isozyme; PFKFB; Cardiac; PFK-2/FBPase-2;

Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Biological Process

Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Glucose catabolic processIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Lactate metabolic processIEA:Ensembl
Positive regulation of glucokinase activityIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Response to glucoseIEA:Ensembl

Cellular Location

cytosol
nucleoplasm

PTM

Phosphorylation by AMPK stimulates activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-PFKFB2 Recombinant Antibody (D5I5F) (CAT#: CBMAB-CP1937-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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